Charged Metallopolymer-Grafted Silica Nanoparticles for Antimicrobial Applications
| Autor: | Tianyu Zhu, Yucheng Huang, Brian C. Benicewicz, Alan W. Decho, Parasmani Pageni, Marpe Bam, Mitzi Nagarkatti, Chuanbing Tang, Yung Pin Chen, Peng Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Gram-negative bacteria
Polymers and Plastics medicine.drug_class Gram-positive bacteria Antibiotics Static Electricity Nanoparticle Metal Nanoparticles Bioengineering 02 engineering and technology Penicillins 010402 general chemistry Gram-Positive Bacteria 01 natural sciences Hemolysis Article Biomaterials Mice Antibiotic resistance Gram-Negative Bacteria Materials Chemistry medicine Animals biology Chemistry Cobalt 021001 nanoscience & nanotechnology Antimicrobial biology.organism_classification Silicon Dioxide Combinatorial chemistry 0104 chemical sciences Anti-Bacterial Agents Penicillin Methacrylates 0210 nano-technology Bacteria medicine.drug |
| Popis: | Inappropriate and frequent use of antibiotics has led to the development of antibiotic-resistant bacteria, which cause infectious diseases that are difficult to treat. With the rising threat of antibiotic resistance, the need to develop effective new antimicrobial agents is prominent. We report antimicrobial metallopolymer nanoparticles, which were prepared by surface-initiated reversible addition-fragmentation chain transfer polymerization of a cobaltocenium-containing methacrylate monomer from silica nanoparticles. These particles are capable of forming a complex with β-lactam antibiotics, such as penicillin, rejuvenating the bactericidal activity of the antibiotic. Disk diffusion assays showed significantly increased antibacterial activities against both Gram-positive and Gram-negative bacteria. The improved efficiencies were attributed to the inhibition of hydrolysis of the β-lactam antibiotics and enhancement of local antibiotics concentration on a nanoparticle surface. In addition, hemolysis evaluations demonstrated minimal toxicity to red blood cells. |
| Databáze: | OpenAIRE |
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