Artemisia pallensalleviates acetaminophen induced toxicity via modulation of endogenous biomarkers
| Autor: | Varsha S. Honmore, Supada R. Rojatkar, Arun D. Natu, Subhash L. Bodhankar, Amit D. Kandhare, Anand A. Zanwar |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Antioxidant medicine.medical_treatment Pharmaceutical Science Aspartate transaminase Pharmacology Kidney Kidney Function Tests medicine.disease_cause Nephrotoxicity Liver Function Tests Oral administration Drug Discovery medicine Animals Rats Wistar Acetaminophen Dose-Response Relationship Drug biology Plant Extracts Chemistry Body Weight digestive oral and skin physiology Organ Size General Medicine Analgesics Non-Narcotic Plant Components Aerial Artemisia pallens Artemisia Liver Complementary and alternative medicine Toxicity biology.protein Molecular Medicine Biomarkers Oxidative stress medicine.drug |
| Zdroj: | Pharmaceutical Biology. 53:571-581 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.3109/13880209.2014.934382 |
| Popis: | Acetaminophen (APAP) leads to severe hepatic and renal necrosis and thus causes significant clinical problems. Artemisia pallens Walls ex D.C. (Asteraceae) possesses various pharmacological properties such as antidiabetic, antioxidant, analgesic, and anti-inflammatory activity.The objective was to evaluate the protective effects of Artemisia pallens methanol extract (APME) in APAP-induced hepatic and nephro-toxicity.The methanolic extract of aerial parts of Artemisia pallens (APME) was prepared. Toxicity was induced in male Wistar rats (180-220 g) by administration of APAP (700 mg/kg, p.o., 14 d). APME (100, 200, and 400 mg/kg, p.o.) was administered to rats 2 h before APAP oral administration. Various biochemical and molecular parameters along with histopathological aberration were studied in the kidney and liver of rats.Pretreatment with APME (200 and 400 mg/kg, p.o.) significantly (p 0.01 and p 0.001) decreased aspartate transaminase (AST), alanine transaminase (ALT), bilirubin, blood urea nitrogen (BUN), and serum creatinine as compared with APAP-treated rat. Decreased level of serum albumin, serum uric acid, and HDL were significantly (p 0.01 and p 0.001) restored by APME (200 and 400 mg/kg, p.o.) pre-treatment. Administration of APME (200 and 400 mg/kg, p.o.) significantly (p 0.01 and p 0.001) reduced the elevated level of cholesterol, LDL, LDH, triglyceride, and VLDL. It also significantly (p 0.01 and p 0.001) restored the altered level of hepatic and renal antioxidant enzymes (superoxide dismutase (SOD) and glutathione (GSH)). The increased level of malondialdehyde (MDA) and nitric oxide (NO) in hepatic as well as renal tissue was significantly (p 0.01 and p 0.001) decreased by APME (200 and 400 mg/kg, p.o.) administration. Histological alternation induced by APAP in liver and kidney was also reduced by the APME (200 and 400 mg/kg, p.o.) pre-treatment.It is concluded that the methanol extract of Artemisia pallens alleviates APAP induced in rats toxicity through its antioxidative and anti-inflammatory actions. |
| Databáze: | OpenAIRE |
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