Enantioselective amination of nitroolefins under base-free and water-rich conditions using chiral bifunctional phase-transfer catalysts
| Autor: | Weiping Chen, Jingxu He, Dong-Xiao Cui, Yue-Dan Li, Jun-Chao Zhu, Ping-An Wang |
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| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Chemistry Organic Chemistry Base free Enantioselective synthesis 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Phase (matter) Physical and Theoretical Chemistry Bifunctional Amination |
| Zdroj: | Organic & Biomolecular Chemistry. 16:3012-3017 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c8ob00583d |
| Popis: | The direct enantioselective amination of nitroolefins has been performed with l-tert-leucine-derived squaramide-scaffold bifunctional phase-transfer catalysts under base-free and water-rich conditions with low catalyst loading (0.5-1 mol%) to provide 2-aminonitroalkanes in good yields (up to 96%) and enantioselectivities (up to 93% ee). |
| Databáze: | OpenAIRE |
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