Regional Structural Hippocampal Differences Between Dementia with Lewy Bodies and Parkinson's Disease
| Autor: | Jeroen van der Grond, Johanna M.L. Henselmans, Anne Hafkemeijer, Jacobus J. van Hilten, Laura J. de Schipper, Johan Marinus |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Research Report
Lewy Body Disease Male 0301 basic medicine Pathology medicine.medical_specialty Parkinson's disease hippocampus Caudate nucleus Hippocampal formation Grey matter shape 03 medical and health sciences Cellular and Molecular Neuroscience Imaging Three-Dimensional 0302 clinical medicine Atrophy medicine Humans magnetic resonance imaging structure Gray Matter Aged Dementia with Lewy bodies business.industry Putamen Brain Parkinson Disease medicine.disease Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure nervous system Parkinson’s disease Female Neurology (clinical) Lewy body dementia business 030217 neurology & neurosurgery Parahippocampal gyrus |
| Zdroj: | Journal of Parkinson's Disease Journal of Parkinson's Disease, 9(4), 775-783 |
| Popis: | Background Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) are considered subtypes of the α-synucleinopathy continuum that show similar and dissimilar clinical and morphological features. Objective To further our understanding of brain abnormalities that might differentiate both disorders more clearly, we performed quantitative magnetic resonance (MR) imaging of the subcortical and cortical grey matter. Methods Three-dimensional T1 weighted 3 tesla MR images of 14 DLB and 62 age- and gender-matched PD patients were examined to study cortical and subcortical grey matter structure. We used volumetric measurements to study total grey matter, and volumes of the pallidum, amygdala, putamen, caudate nucleus, thalamus and hippocampus. Whole-brain and structural network-based methods were used to identify local differences in grey matter and vertex-based shape analysis was used to assess focal hippocampal changes. Results Volumetric, whole-brain and network-based analyses showed reduced hippocampal (p = 0.008) and right parahippocampal region volumes (p = 0.030) in DLB compared to PD patients. Shape analysis showed atrophy in the head and body of the right (p = 0.040) and in the head of the left (p = 0.030) hippocampus of DLB patients. Conclusion DLB patients showed atrophy of the hippocampus and parahippocampal gyrus compared to PD patients with a differential involvement of the head and body of the hippocampus. Further studies should examine if these group-based findings can be used to differentiate both disorders on an individual level. |
| Databáze: | OpenAIRE |
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