A promoter polymorphism in the gene encoding interleukin-12 p40 (IL12B) is associated with mortality from cerebral malaria and with reduced nitric oxide production
| Autor: | Dexing Huang, J.R. Saunders, Kevin Marsh, Maurine R. Hobbs, Donald L. Granger, David J. Roberts, E.D. Mwaikambo, Arnab Pain, Craig S. Boutlis, J B Weinberg, N Peshu, Nicholas M. Anstey, Grant Morahan |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Plasmodium
medicine.medical_treatment Molecular Sequence Data Immunology Malaria Cerebral Biology Nitric Oxide Tanzania Nitric oxide chemistry.chemical_compound Immunity parasitic diseases Genetics medicine Animals Humans Promoter Regions Genetic Genetics (clinical) Type 1 diabetes Polymorphism Genetic Interleukin-12 Subunit p40 Promoter medicine.disease Interleukin-12 Kenya Protein Subunits Cytokine chemistry Cerebral Malaria Interleukin 12 Malaria |
| Zdroj: | Genes and immunity. 3(7) |
| ISSN: | 1476-5470 1466-4879 |
| Popis: | Interleukin-12 (IL-12) is an important regulatory cytokine in infection and immunity. Administration of IL-12 may reduce complications of severe malaria in rodents. Polymorphisms in IL12B, the gene encoding the IL-12 p40 subunit, influence the secretion of IL-12 and susceptibility to Type 1 diabetes. We therefore investigated whether IL12B polymorphisms may affect the outcome of severe malaria. Homozygosity for a polymorphism in the IL12B promoter was associated with increased mortality in Tanzanian children having cerebral malaria but not in Kenyan children with severe malaria. Furthermore, homozygotes for the IL12B promotor polymorphism had decreased production of nitric oxide, which is in part regulated by IL-12 activity. These studies suggest that IL12B polymorphisms, via regulation of IL-12 production, may influence the outcome of malaria infection in at least one African population. |
| Databáze: | OpenAIRE |
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