Design verification of a compact system for detecting tissue perfusion using bimodal diffuse optical technologies
| Autor: | Sara Zanfardino, Noah J. Kolodziejski, Taylor L. Hedrick, Michael C. Helton, Karthik Vishwanath, James F. Christian, Mary Ann Mycek, Julia M. Pakela, Christopher J. Stapels, Daniel R. McAdams, Seung Yup Lee, Stephen E. Feinberg, Daniel E. Fernandez, Yooree G. Chung |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Diffuse reflectance infrared fourier transform Computer science Blood flow Diffuse correlation spectroscopy 01 natural sciences Article 010309 optics Flow phantom 03 medical and health sciences 0302 clinical medicine 0103 physical sciences medicine Medical physics Perfusion 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Optical Diagnostics and Sensing XVII: Toward Point-of-Care Diagnostics. |
| DOI: | 10.1117/12.2252811 |
| Popis: | It is essential to monitor tissue perfusion during and after reconstructive surgery, as restricted blood flow can result in graft failures. Current clinical procedures are insufficient to monitor tissue perfusion, as they are intermittent and often subjective. To address this unmet clinical need, a compact, low-cost, multimodal diffuse correlation spectroscopy and diffuse reflectance spectroscopy system was developed. We verified system performance via tissue phantoms and experimental protocols for rigorous bench testing. Quantitative data analysis methods were employed and tested to enable the extraction of tissue perfusion parameters. This design verification study assures data integrity in future in vivo studies. |
| Databáze: | OpenAIRE |
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