The effect of cetylpyridinium chloride mouthrinse as adjunct to toothbrushing compared to placebo on interproximal plaque and gingival inflammation-a systematic review with meta-analyses
| Autor: | Francisco Wilker Mustafa Gomes Muniz, Taciane Menezes da Silveira, Ricardo dos Santos Araújo Costa, Gerson Pedro José Langa, Cassiano Kuchenbecker Rösing |
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| Rok vydání: | 2020 |
| Předmět: |
Toothbrushing
Mouthwashes Dentistry Cetylpyridinium Dental plaque Placebo Cetylpyridinium chloride law.invention 03 medical and health sciences Gingivitis chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law medicine Humans Gingival inflammation General Dentistry Inflammation business.industry Dental Plaque Index 030206 dentistry medicine.disease Confidence interval chemistry 030220 oncology & carcinogenesis Meta-analysis Anti-Infective Agents Local medicine.symptom business |
| Zdroj: | Clinical oral investigations. 25(2) |
| ISSN: | 1436-3771 |
| Popis: | The present study aimed to systematically review the literature about the interproximal anti-plaque and anti-gingivitis efficacy of cetylpyrydinium chloride (CPC) mouthrinse compared to placebo solution. Three databases (PUBMED, SCOPUS, and EMBASE) were searched for randomized clinical trials that compared the interproximal anti-plaque and anti-gingivitis effect of CPC and placebo mouthrinses as an adjunct to toothbrushing, after a minimum of 6 weeks. Individuals with any periodontal diagnosis were considered. Two meta-analyses were performed for the Turesky modification of the Quigley-Hein plaque index and the Loe and Silness gingival index. For both analyses, the mean differences (MD) between baseline and 6-weeks were calculated using a random-effect model. Eight studies were included. All included studies showed significant improvement in at least one of the parameters, favoring the CPC mouthrinse when compared to placebo. The meta-analysis demonstrated that groups that used CPC displayed a significantly greater reduction in the plaque index score (MD; 95% confidence interval [95%CI]: − 0.70; − 0.83 to − 0.57) and in the gingival index (MD; 95%CI: − 0.38; − 0.47 to − 0.28) when compared to placebo. However, high heterogeneity was observed in both analyses (I2 = 89% and I2 = 98%, respectively). When considering interproximal surfaces, CPC is efficacious both in plaque and gingival inflammatory parameters, demonstrating the potential to compensate for the limitations of interproximal plaque control. CPC may be a good alternative to compensate interproximal plaque removal, improving interproximal gingivitis |
| Databáze: | OpenAIRE |
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