Longitudinal analysis of cardiac structure and function in incident-automated peritoneal dialysis: comparison between icodextrin solution and glucose-based solution
Autor: | Wen-Hao Liu, Cheng-Hong Yang, Ben-Chung Cheng, Mao-Young Morgan Fu, Jin-Bor Chen, Sin-Hua Moi, Shang-Chih Liao |
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Rok vydání: | 2017 |
Předmět: |
Nephrology
Cardiac function curve Male Multivariate statistics medicine.medical_specialty Heart Diseases medicine.medical_treatment Echocardiogram 030232 urology & nephrology 030204 cardiovascular system & hematology lcsh:RC870-923 Icodextrin Ventricular Function Left Peritoneal dialysis 03 medical and health sciences 0302 clinical medicine Glucose-based solution Internal medicine Dialysis Solutions medicine Humans Cardiac structure Longitudinal Studies Prospective Studies Ejection fraction business.industry Incidence Icodextrin Solution Heart lcsh:Diseases of the genitourinary system. Urology Automated peritoneal dialysis Icodextrin solution Glucose Cardiology Female Kidney Diseases business Peritoneal Dialysis Research Article |
Zdroj: | BMC Nephrology BMC Nephrology, Vol 19, Iss 1, Pp 1-9 (2018) |
ISSN: | 1471-2369 |
Popis: | Background This study aimed to evaluate the longitudinal changes in cardiac structure and function in incident-automated peritoneal dialysis (APD) patients. Methods We conducted a 2-year prospective, randomized, open-label, parallel-group study to compare the efficacy of icodextrin solution versus glucose-based solution. Echocardiography was performed at baseline, 1 and 2 years. Echocardiographic parameters over 2 years were evaluated for each group, using the Friedman test. Generalized linear regression analysis was used to test the associations between baseline clinical variables and echocardiographic changes, and a multivariate model was used to analyze cardiac function between the two groups. Results A total of 43 APD patients were enrolled in the beginning of this study. Twenty patients in the icodextrin group (ICO) and 18 patients in the glucose group (GLU) completed the study. In left ventricular (LV) systolic function measurements, ejection fraction (EF) increased significantly in the GLU group. Measurements of LV diastolic function and septal early mitral annulus velocity (EMV) increased significantly from baseline to 24-months in the ICO group (5.43–5.51 ms). The GLU group showed a significant decrease in peak early diastolic velocity (EDV) (70.67–68.25 cm/s), but a significant increase in septal EMV (5.94–7.57 ms) from baseline to 24-months. No significant association was found between the baseline clinical variables and echocardiographic changes within 24 months in the generalized linear regression analysis. Multivariate models were used to investigate changes in the four primary endpoints, namely, myocardial performance index (MPI), left ventricular ejection fraction (LVEF), deceleration time (DT), and E/e′ ratio. These primary endpoints show no significant association with the baseline values in both the ICO and GLU groups. Conclusion The present study demonstrates that long-dwell icodextrin solution can maintain reasonable cardiac structure and function in incident-APD patients. Trial registration ISRCTN14931270 (retrospectively registered on 23/03/2018). |
Databáze: | OpenAIRE |
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