Evaluation of 50-kHz ultrasonic vocalizations in animal models of mania: Ketamine and lisdexamfetamine-induced hyperlocomotion in rats
Autor: | Markus Wöhr, Luiz Kae Sales Kanazawa, Palloma de Almeida Soares Hocayen, Etieli Wendler, Rainer K.W. Schwarting, Débora Dalla Vecchia, Roberto Andreatini, Camila Pasquini de Souza |
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Rok vydání: | 2016 |
Předmět: |
Male
Bipolar Disorder Lithium (medication) Hyperkinesis Motor Activity Pharmacology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lithium Carbonate Antimanic Agents Dopamine medicine Animals Pharmacology (medical) Ketamine Bipolar disorder Lisdexamfetamine Dimesylate Rats Wistar Biological Psychiatry Lithium carbonate Single parameter medicine.disease Rats 030227 psychiatry Disease Models Animal Psychiatry and Mental health Lisdexamfetamine Neurology chemistry Anesthesia Central Nervous System Stimulants Neurology (clinical) Vocalization Animal medicine.symptom Psychology Excitatory Amino Acid Antagonists Mania 030217 neurology & neurosurgery medicine.drug |
Zdroj: | European Neuropsychopharmacology. 26:1900-1908 |
ISSN: | 0924-977X |
Popis: | Drug-induced hyperlocomotion in rodents is frequently used as a behavioral model for mania. However, the use of locomotor activity as the single parameter in these animal models of mania may pose some limitations for developing new pharmacological treatments. Thus, alternative behavioral markers are required. Fifty-kHz ultrasonic vocalizations (USV), which are thought to represent positive affect, are increased by the administration of the psychostimulant d-amphetamine, an effect that can be prevented by lithium treatment, the gold standard antimanic drug for treating bipolar disorder. The aim of this study was to evaluate 50-kHz USV in two other pharmacological-induced animal models of mania: ketamine (KET)- and lisdexamfetamine (LDX)-induced hyperlocomotion. After systemic injection of LDX (10mg/kg, ip), racemic-ketamine (25mg/kg, ip) or S-ketamine (25mg/kg, ip), locomotor activity and 50-kHz USV emission were evaluated in rats. Furthermore, the effects of an antimanic treatment, namely lithium carbonate (100mg/kg, ip), on LDX-induced 50-kHz USV and hyperlocomotion were tested. Rats treated with racemic KET and S-KET showed increased locomotor activity, but these drug treatments did not significantly affect 50-kHz USV emission rates. On the other hand, LDX administration increased both locomotor activity and 50-kHz USV with both effects being reversed by lithium administration. The present findings suggest that 50-kHz USV can differentiate between drug-induced models of mania, which may represent different types of manic episodes. Thus, measuring 50-kHz USV might serve as an additional valuable behavioral variable to assess mania-like phenotypes in rat models. |
Databáze: | OpenAIRE |
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