Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease
| Autor: | Graeme Brendon Jacobs, Mbanyamsig Mispa Yivala, Eric Walter Pefura-Yone, Bih H. Chendi, Novel N. Chegou, Elise Guiedem, Marie Claire Assoumou Okomo, Céline Nguefeu Nkenfou, George Mondinde Ikomey, Martha Tongo Mesembe |
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| Rok vydání: | 2020 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Adult Male medicine.medical_specialty Vital capacity Allergy Tuberculosis Cells Immunology Severity of Illness Index Pathogenesis Pulmonary Disease Chronic Obstructive 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Internal medicine Tobacco Tobacco Smoking medicine COPD Humans 030212 general & internal medicine Risk factor Tuberculosis Pulmonary Aged Inflammation business.industry Bronchial obstruction Sputum Middle Aged medicine.disease respiratory tract diseases Airway Obstruction 030228 respiratory system Spirometry Disease Progression Cytokines Female medicine.symptom lcsh:RC581-607 business |
| Zdroj: | BMC Immunology, Vol 21, Iss 1, Pp 1-11 (2020) |
| ISSN: | 1471-2172 |
| Popis: | BackgroundPrevious studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually related to noxious particles. Post-TB airflow obstruction and tobacco-related COPD have the same functional pathway characterized by persistent airflow limitation. We sought to compare the profile of 29 cytokines in the sputum of subjects with post-TB airflow obstruction and those with COPD related to tobacco.ResultsThe forced expiratory volume in the first second (FEV1) and forced expiratory volume/forced vital capacity (FEV/FVC) ratio were lower in the COPD patients with the history of smoking compared to the post-TB airflow obstruction subgroup. The stages of the disease were more advanced in COPD / tobacco patients.Among the cytokines, IL-1α, IL-1β, MIP-1β, sCD40L and VEGF levels were higher in COPD patients, compared to the controls withpvalues of 0.003, 0.0001, 0.03, 0.0001 and 0.02 respectively. When the two COPD subgroups were compared, IL-1α, IL-6, TNF-α and IL-8 levels were higher in the COPD patients with the history of tobacco compared to the COPD patients with the history of TB withp-values of 0.031, 0.05, 0.021 and 0.016, respectively.ConclusionCOPD related to tobacco is more severe than post-TB airflow obstruction. The pathogenesis of post-TB airflow obstruction appears to involve the cytokines IL-1RA, IL-1α, IL-1β, IL-17, GRO and sCD40L, while COPD related to tobacco involves more cytokines. |
| Databáze: | OpenAIRE |
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