Apamin, a selective blocker of SK(Ca) channels, inhibits posthypoxic hyperexcitability but does not affect rapid hypoxic preconditioning in hippocampal CA1 pyramidal neurons in vitro
| Autor: | Oleg V. Godukhin, Alina A. Shamsutdinova, Sergei G. Levin |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Small-Conductance Calcium-Activated Potassium Channels General Neuroscience Pyramidal Cells Central nervous system Population spike Iberiotoxin Hypoxia (medical) Hippocampal formation Hypoxic preconditioning Apamin In vitro Rats chemistry.chemical_compound medicine.anatomical_structure nervous system chemistry medicine Animals medicine.symptom Rats Wistar Hypoxia Neuroscience CA1 Region Hippocampal |
| Zdroj: | Neuroscience letters. 484(1) |
| ISSN: | 1872-7972 |
| Popis: | The aim of this study was to investigate the effects of apamin, a selective blocker of SK Ca channels, on the repeated brief hypoxia-induced posthypoxic hyperexcitability and rapid hypoxic preconditioning in hippocampal CA1 pyramidal neurons in vitro. The method of field potentials measurement in CA1 region of the rat hippocampal slices was used. Application of apamin (50 nM) to the hippocampal slices during hypoxic episodes significantly abolished posthypoxic hyperexcitability induced by brief hypoxic episodes. However, in contrast to our previous results with iberiotoxin, a selective blocker of BK Ca channels, apamin significantly enhanced the depressive effect of brief hypoxia on the PS amplitude during hypoxic episode and did not abolish the rapid hypoxic preconditioning in CA1 pyramidal neurons. Present results indicate that SK Ca channels, along with previously implicated BK Ca channels, play an important role in the development of posthypoxic hyperexcitability induced by brief hypoxic episodes in CA1 pyramidal neurons. However, SK Ca channels, in contrast to the BK Ca channels, are not involved in the rapid hypoxic preconditioning in CA1 hippocampal region in vitro. |
| Databáze: | OpenAIRE |
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