Deposition and remodelling of elastic fibres in chronic hepatitis
| Autor: | Pierre Bedossa, Lemaigre G, F. Paraf, E. Martin |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pathology
medicine.medical_specialty Biopsy Hepatitis Pathology and Forensic Medicine Extracellular matrix Necrosis Chronic hepatitis Collagen fibres medicine Humans Molecular Biology Wound Healing Chronic Active business.industry Cell Biology General Medicine Elastic Tissue medicine.disease Fibrosis Elastic fibres medicine.anatomical_structure Liver Chronic Disease Viral hepatitis business Elastic fiber |
| Zdroj: | Virchows Archiv A Pathological Anatomy and Histopathology. 417:159-162 |
| ISSN: | 1432-2307 0174-7398 |
| DOI: | 10.1007/bf02190534 |
| Popis: | A longitudinal study of elastic fibres was conducted in liver biopsies from 21 patients with chronic viral hepatitis. Biopsies were taken at the start of treatment with alpha-interferon, and after 6 months or 1 year of treatment. No elastic fibres could be detected in portal tracts or fibrous septa when inflammation and necrosis were present, whatever the duration of the disease. Once the liver lesions had healed, elastic fibres were synthesized. Fibres were of two types and patterns: at first, they were thin, long and parallel to each other. Later, they were thicker, shorter and tortuous and were closely wrapped around thick bundles of collagen fibres. These findings suggest that the deposition of elastic fibres acts as a marker of healing in chronic active hepatitis and that their remodelling occurs concomitantly with the deposit of large bundles of collagen fibres. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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