Value of the identification of microsatellite instability in colorectal cancer
| Autor: | José Antonio López-Guerrero, Jorge Campos Máñez, Vicente Alapont Olavarrieta, Antonio Barrasa Shaw, Zaida García-Casado, Ana Calatrava Fons, Carlos Vazquez Albaladejo |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Oncology congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Pathology Colorectal cancer Disease-Free Survival Internal medicine Biomarkers Tumor medicine Humans neoplasms Aged business.industry Incidence (epidemiology) nutritional and metabolic diseases Microsatellite instability General Medicine Middle Aged Prognosis medicine.disease digestive system diseases Clinical Practice Microsatellite Stable Microsatellite Female Microsatellite Instability Colorectal Neoplasms business Microsatellite Repeats |
| Zdroj: | Clinical and Translational Oncology. 11:465-469 |
| ISSN: | 1699-3055 1699-048X |
| DOI: | 10.1007/s12094-009-0386-y |
| Popis: | Recent studies defend a possible prognostic and therapeutic value of the identification of microsatellite instability (MSI) in colorectal cancer. This work tries to assess the impact that the identification of MSI tumours can have in clinical practice. We recovered tumour samples from 92 of the 143 patients operated on for colorectal cancer in our institution between 1995 and 2000. Five MSI markers (BAT 25, BAT 26, D2S123, D5S346 and D17S250) were studied on them. The rate and clinicopathologic characteristics of MSI tumours were investigated along with their impact on the global and disease-free survival as compared with microsatellite stable (MSS) tumours. All 5 microsatellite markers’ status were established in 73 patients (79.3% of the samples). Among them, 7 tumours showed instability in just one marker (low microsatellite instability [MSI-L]) whereas 5 tumours had mutations in 2 or more markers (high microsatellite instability [MSI-H]), for a total 15.4% rate of MSI tumours. All MSI-H tumours were located in the right colon. We could not find any impact from MSI detection on global or disease-free survival. MSI determination did not identify groups of patients with a different prognosis. Moreover, with such low incidence its determination can only be justified in those cases that fulfill Bethesda’s criteria to identify families with Lynch’s syndrome. |
| Databáze: | OpenAIRE |
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