Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves
| Autor: | Stefan Pierzynowski, Peter Colin Gregory, Violetta Leśniewska, Jürgen Borlak, Pawel R. Kiela, Romuald Zabielski, W. Barej |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Atropine
Male medicine.medical_specialty Physiology Clinical Biochemistry Biology Biochemistry Sincalide Cellular and Molecular Neuroscience Benzodiazepines Endocrinology Pancreatic Juice Internal medicine medicine Animals Secretion Pancreas Migrating motor complex Pancreatic duct Pancreatic Exocrine Secretion Electromyography digestive oral and skin physiology Small intestine Receptor Cholecystokinin A Electrophysiology medicine.anatomical_structure Postprandial Duodenum Cattle Receptors Cholecystokinin Gastrointestinal Motility hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Regulatory peptides. 78(1-3) |
| ISSN: | 0167-0115 |
| Popis: | The influence of CCK-A receptor antagonism on pancreatic exocrine secretion and duodenal EMG, and the mechanism(s) involved in CCK-induced pancreatic secretion were studied in conscious calves. Seven 1-week-old calves were fitted with a pancreatic duct catheter, duodenal cannula and duodenal electrodes. Pancreatic exocrine secretion and duodenal EMG were studied following intraduodenal CCK-A receptor antagonist (Tarazepide), intravenous atropine, and intravenous or intraduodenal CCK-8 administrations. Tarazepide decreased duodenal electric activity, reduced interdigestive pancreatic secretion, especially protein; reduced cephalic and early postprandial (milk) induced secretion of bicarbonate and protein. Pancreatic protein secretion to intravenous CCK-8 was little affected by atropine, but was significantly reduced by Tarazepide±atropine; in contrast, protein secretion to intraduodenal CCK-8 was abolished by Tarazepide or atropine. We conclude that pre- and especially early postprandial pancreatic secretion are partly controlled via CCK-A (mainly mucosal) mediated mechanisms. |
| Databáze: | OpenAIRE |
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