Gene-environment interactions in obesity: implication for future applications in preventive medicine

Autor:	Takamasa Kayama, Shigeru Karasawa, Makoto Daimon, Ryo Kawasaki, Hidetoshi Yamashita, Akira Fukao, Sho Nakamura, Hiroto Narimatsu, Katsumi Otani, Takeo Kato, Isao Kubota, Ri Sho, Takashi Yoshioka, Yoshiyuki Ueno, Hidenori Sato
Rok vydání:	2015
Předmět:	0301 basic medicine Adult medicine.medical_specialty Genotype Population Biology Polymorphism Single Nucleotide Body Mass Index 03 medical and health sciences Risk Factors Environmental health Genetics medicine Genetic predisposition Humans Genetic Predisposition to Disease Obesity Gene–environment interaction education Prospective cohort study Genetics (clinical) Preventive healthcare Aged Aged 80 and over education.field_of_study fungi Middle Aged medicine.disease 030104 developmental biology Genetic epidemiology Gene-Environment Interaction Body mass index
Zdroj:	Journal of human genetics. 61(4)
ISSN:	1435-232X
Popis:	Obesity is associated with environmental factors; however, information about gene-environment interactions is lacking. We aimed to elucidate the effects of gene-environment interactions on obesity, specifically between genetic predisposition and various obesity-related lifestyle factors, using data from a population-based prospective cohort study. The genetic risk score (GRS) calculated from East Asian ancestry single-nucleotide polymorphisms was significantly associated with the body mass index (BMI) at baseline (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dee423df1a726ea21eb0fd9286bdad9 https://pubmed.ncbi.nlm.nih.gov/26657934 Zobrazit plný text záznamu Full text from SpringerLink