Hypersensitivity Reactions to Cancer Chemotherapy: Practical Recommendations of ARADyAL for Diagnosis and Desensitization
| Autor: | María José Torres, Maria Del Carmen Dieguez, B. de la Hoz Caballer, M Fernández-Rivas, Arantza Vega, M P Berges-Gimeno, M Gandolfo-Cano, L Sánchez-Morillas, G Gastaminza-Lasarte, Eloína González-Mancebo, Rosa Muñoz-Cano, R. Barranco, Inmaculada Doña, Joan Bartra, T W Jimenez-Rodriguez |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
Allergy Cancer chemotherapy Drug desensitization medicine.drug_class medicine.medical_treatment media_common.quotation_subject Immunology Drug allergy Desensitization Bioinformatics Monoclonal antibody Drug Hypersensitivity Antineoplastic Agents Immunological Neoplasms medicine Chemotherapy Humans Immunology and Allergy Drug challenge Desensitization (medicine) media_common business.industry Antibodies Monoclonal medicine.disease Desensitization Immunologic Monoclonal antibodies business Drug hypersensitivity |
| Zdroj: | JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname |
| ISSN: | 1018-9068 |
| DOI: | 10.18176/jiaci.0712 |
| Popis: | Rapid drug desensitization has enabled first-line therapies in patients with drug hypersensitivity reactions to chemotherapeutic drugs including monoclonal antibodies. Desensitization is a safe and highly effective procedure, not only for IgE-mediated reactions, but also for those mediated by non-IgE mechanisms. The likelihood of breakthrough reactions during desensitization is low, and most are mild; in fact, moderate-to-severe reactions are infrequent. In this document, 16 allergy departments belonging to the Spanish research network ARADyAL present a review of the available scientific evidence and provide general guidelines for the diagnosis and management of drug hypersensitivity reactions to chemotherapeutic drugs and monoclonal antibodies. Emphasis is placed on the desensitization procedure. |
| Databáze: | OpenAIRE |
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