Role of Population Receptive Field Size in Complex Visual Dysfunctions

Autor: Yoni Pertzov, Netta Levin, Serge O. Dumoulin, Noa Raz, Pieter B de Best, Nitzan Guy, Tamir Ben-Hur
Přispěvatelé: Cognitive Psychology, Spinoza Centre for Neuroimaging
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: JAMA Neurology, 76(11), 1391-1396. American Medical Association
De Best, P B, Raz, N, Guy, N, Ben-Hur, T, Dumoulin, S O, Pertzov, Y & Levin, N 2019, ' Role of Population Receptive Field Size in Complex Visual Dysfunctions : A Posterior Cortical Atrophy Model ', JAMA Neurology, vol. 76, no. 11, pp. 1391-1396 . https://doi.org/10.1001/jamaneurol.2019.2447
JAMA Neurology, 76, 1391-1396. American Medical Association
JAMA Neurol
ISSN: 2168-6149
DOI: 10.1001/jamaneurol.2019.2447
Popis: Importance: The neuronal mechanism of visual agnosia and foveal crowding that underlies the behavioral symptoms of several classic neurodegenerative diseases, including impaired holistic perception, navigation, and reading, is still unclear. A better understanding of this mechanism is expected to lead to better treatment and rehabilitation. Objective: To use state-of-the-art neuroimaging protocols to assess a hypothesis that abnormal population receptive fields (pRF) in the visual cortex underlie high-order visual impairments. Design, Setting, and Participants: Between April 26 and November 21, 2016, patients and controls were recruited from the Hadassah-Hebrew University medical center in a cross-sectional manner. Six patients with posterior cortical atrophy (PCA) were approached and 1 was excluded because of an inability to perform the task. Participants underwent functional magnetic resonance imaging-based cortical visual field mapping and pRF evaluation and performed a masked repetition priming task to evaluate visuospatial perception along the eccentricity axis. The association between pRF sizes and behavioral impairments was assessed to evaluate the role of abnormal pRF sizes in impaired visual perception. Posterior cortical atrophy is a visual variant of Alzheimer disease that is characterized by progressive visual agnosia despite almost 20/20 visual acuity. Patients with PCA are rare but invaluable for studying visual processing abnormalities following neurodegeneration, as atrophy begins in visual cortices but initially spares other brain regions involved in memory and verbal communication. Exposures: Participants underwent a magnetic resonance imaging scan. Main Outcomes and Measures: Population receptive field sizes and their association with visual processing along the fovea-to-periphery gradient. Results: Five patients with PCA (4 men [80%]; mean [SEM] age, 62.9 [3.5] years) were compared with 8 age-matched controls (1 man [25%]; mean [SEM] age, 63.7 [3.7] years) and demonstrated an atypical pRF mapping that varied along the eccentricity axis, which presented as abnormally small peripheral and large foveal pRFs sizes. Abnormality was seen in V1 (peripheral, 4.4° and 5.5°; foveal, 5.5° and 4.5° in patients and controls, respectively; P
Databáze: OpenAIRE
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