Comparison between traditional and nontraditional add-on devices used with pressurised metered-dose inhalers
| Autor: | Haitham Saeed, Youssef M.A. Soliman, Mina Nicola, Raghda R S Hussein, Mohamed E. A. Abdelrahim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Inhalation Young child business.industry lcsh:R lcsh:Medicine Water bottle HOLDING CHAMBER 030226 pharmacology & pharmacy 03 medical and health sciences Aerosol delivery 0302 clinical medicine 030228 respiratory system Salbutamol medicine AEROCHAMBER PLUS business medicine.drug Biomedical engineering |
| Zdroj: | ERJ Open Research, Vol 6, Iss 4 (2020) |
| ISSN: | 2312-0541 |
| Popis: | Add-on devices that are attached to metered-dose inhalers (MDIs) were introduced to improve aerosol delivery. The objective of this study was to determine the efficacy of drug delivery from an MDI when attached to different add-on devices at different inhalation volumes.The total emitted dose (TED) of salbutamol was estimated for the MDI alone and the MDI connected to five different add-on devices (Able valved holding chamber, Tips-haler valved holding chamber, Aerochamber plus flow Vu valved holding chamber, Dolphin chamber, and a handmade water bottle spacer), at inhalation flow of 28.3 L·min−1 with flow volume of 1, 2 and 4 L, assuming young child (aged 6 years) and adult inhalation volumes, respectively.The TED% ranged between 84.1% and 87.2% at all inhalation volumes from the MDI alone, which was significantly greater than all MDI add-on device combinations (pThis study suggests that antistatic add-on devices delivered much more aerosol than non-antistatic add-on devices. However, it may be advised to still use a non-antistatic add-on device, for the sake of solving the coordination problem, and wash it with light detergent before use to improve TED. |
| Databáze: | OpenAIRE |
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