Androgen deprivation therapy and cognitive decline-associations with brain connectomes, endocrine status, and risk genotypes
| Autor: | Cecilie R. Buskbjerg, S. M. Hadi Hosseini, Ali Amidi, Simon Buus, Robert Zachariae, Claus Højbjerg Gravholt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Genotype Cognitive Dysfunction/chemically induced Urology 030232 urology & nephrology Catechol O-Methyltransferase/genetics Spatial memory Androgen deprivation therapy 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine medicine Connectome Humans Testosterone Effects of sleep deprivation on cognitive performance Cognitive decline business.industry Brain-Derived Neurotrophic Factor/genetics Cognition medicine.disease Brain/diagnostic imaging 030220 oncology & carcinogenesis Androgens Prostatic Neoplasms/drug therapy Verbal memory business Apolipoproteins E/genetics Androgen Antagonists/adverse effects |
| Zdroj: | Buskbjerg, C R, Amidi, A, Buus, S, Gravholt, C H, Hadi Hosseini, S M & Zachariae, R 2022, ' Androgen deprivation therapy and cognitive decline-associations with brain connectomes, endocrine status, and risk genotypes ', Prostate Cancer and Prostatic Diseases, vol. 25, no. 2, pp. 208-218 . https://doi.org/10.1038/s41391-021-00398-1 |
| Popis: | BACKGROUND: Evidence suggests that prostate cancer (PC) patients undergoing androgen deprivation therapy (ADT) are at risk for cognitive decline (CD), but the underlying mechanisms are less clear. In the present study, changes in cognitive performance and structural brain connectomes in PC patients undergoing ADT were assessed, and associations of cognitive changes with endocrine status and risk genotypes were explored.METHODS: Thirty-seven PC patients underwent cognitive assessment, structural MRI, and provided blood samples prior to ADT and after 6 months of treatment. Twenty-seven age- and education-matched healthy controls (HCs) underwent the same assessments. CD was determined using a standardized regression-based approach and defined as z-scores ≤ -1.64. Changes in brain connectomes were evaluated using graph theory. Associations of CD with testosterone levels and genotypes (APOE, COMT, BDNF) were explored.RESULTS: Compared with HCs, PC patients demonstrated reduced testosterone levels (p CONCLUSIONS: Our results indicate that PC patients undergoing ADT may evidence CD, and that COMT Met homozygotes may be at increased risk of CD. The results did not reveal changes in brain connectomes or testosterone levels as underlying mechanisms. More research evaluating the role of ADT-related disruption of the dynamics of the hypothalamic-pituitary-gonadal axis is needed. |
| Databáze: | OpenAIRE |
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