A fluvoxamine-related fatality: Case report with postmortem concentrations
| Autor: | Jenna Otter, Lee Cantrell, Iain M. McIntyre, Jacquelyn Morhaime |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Obtundation Serotonin reuptake inhibitor Fluvoxamine 01 natural sciences QT interval Gas Chromatography-Mass Spectrometry Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Limit of Detection Cardiac conduction medicine Humans 030216 legal & forensic medicine Cause of death business.industry 010401 analytical chemistry Middle Aged medicine.disease Peripheral blood 0104 chemical sciences Liver Anesthesia Toxicity Drug Overdose business Law Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Forensic Science International. 300:e31-e33 |
| ISSN: | 0379-0738 |
| Popis: | Fluvoxamine is a selective serotonin reuptake inhibitor that has been considered relatively safe in overdose. At therapeutic and supratherapeutic concentrations, fluvoxamine affects cardiac conduction, prolongs QTc interval, causes hypotension, obtundation, and can increase propensity for seizures. A man in his 60s was found dead at his home with a postmortem fluvoxamine peripheral blood concentration of 4.9 mg/L, and a liver concentration of 440 mg/kg. His cause of death was determined to be acute fluvoxamine toxicity. |
| Databáze: | OpenAIRE |
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