ACPA-positive versus ACPA-negative rheumatoid arthritis: two distinct erosive disease entities on radiography and ultrasonography
| Autor: | D. Loeuille, I. Chary-Valckenaere, Camille Roux, Isabelle Clerc-Urmès, Marcelo De Carvalho-Bittencourt, Eliane Albuisson, Julien Grosse, Thomas Remen, Audrey Pierreisnard, Edem Allado, Marion Couderc |
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| Přispěvatelé: | Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Service d'Immunologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Rhumatologie [CHRU Nancy], Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Plateforme d'Aide à la Recherche Clinique [CHRU Nancy] (PARC), Centre d'investigation clinique - Epidémiologie clinique [Nancy] (CIC-EC), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Hand Joints Radiography Immunology Enzyme-Linked Immunosorbent Assay Disease Bone erosion Anti-Citrullinated Protein Antibodies Facet joint Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases Internal medicine Foot Joints medicine Immunology and Allergy Humans In patient 030212 general & internal medicine skin and connective tissue diseases ComputingMilieux_MISCELLANEOUS Aged Retrospective Studies Ultrasonography 030203 arthritis & rheumatology business.industry Middle Aged medicine.disease medicine.anatomical_structure Rheumatoid arthritis Disease Progression Female business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Rheumatology International Rheumatology International, Springer Verlag, 2020, 40 (4), pp.615-624. ⟨10.1007/s00296-019-04492-5⟩ Rheumatology International, 2020, 40 (4), pp.615-624. ⟨10.1007/s00296-019-04492-5⟩ |
| ISSN: | 0172-8172 1437-160X |
| Popis: | The objective of this study is to assess the prevalence, localization, and severity of bone erosions on radiography (RX) and ultrasonography (US) according to ACPA status in patients with rheumatoid arthritis (RA). 78 patients with ACPA-positive (ACPA+) RA and 30 patients with ACPA-negative (ACPA−) RA fulfilling the ACR 1987 and/or ACR/EULAR 2010 criteria were consecutively included. On RX, a modified Sharp erosion score (SHSe) was evaluated by two blinded readers and one adjudicator for discordant cases (number of eroded joints ≤ three). On US, erosions were scored on six bilateral joints (MCP2, 3, 5; MTP2, 3, 5) with a four-point scale to calculate the total US score for erosions (USSe). The mean total SHSe and USSe were 3.7 and 4.4 times higher in the ACPA+ group than in the ACPA− group, respectively (P |
| Databáze: | OpenAIRE |
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