Evaluation of Left Cardiac Chamber Function with Cardiac Magnetic Resonance and Association with Outcome in Patients with Systemic Sclerosis
| Autor: | Steele C Butcher, Jacqueline L Vos, Federico Fortuni, Xavier Galloo, Sophie I E Liem, Jeroen J Bax, Victoria Delgado, Madelon C Vonk, Sander I van Leuven, Miranda Snoeren, Saloua El Messaoudi, Jeska K de Vries-Bouwstra, Robin Nijveldt, Nina Ajmone Marsan |
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| Přispěvatelé: | Cardiology |
| Rok vydání: | 2022 |
| Předmět: |
ventricular
All institutes and research themes of the Radboud University Medical Center strain Rheumatology Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] feature-tracking Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5] left atrial Pharmacology (medical) CMR SSc Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| Zdroj: | Rheumatology, 62, SI, pp. SI20-SI31 Rheumatology r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname Rheumatology, 62, SI20-SI31 Rheumatology, 62(1), S120-S131. OXFORD UNIV PRESS |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objective This study aimed to determine whether lower values of feature-tracking cardiovascular magnetic resonance (CMR)-derived left atrial reservoir strain (LARS) and impaired left ventricular (LV) global longitudinal strain (GLS) were associated with the presence of symptoms and long-term prognosis in patients with SSc. Methods A total of 100 patients {54 [interquartile range (IQR) 46–64] years, 42% male} with SSc who underwent CMR imaging at two tertiary referral centres were included. All patients underwent analysis of LARS and LV GLS using feature-tracking on CMR and were followed-up for the occurrence of all-cause mortality. Results The median LV GLS was –21.8% and the median LARS was 36%. On multivariable logistic regression, LARS [odds ratio (OR) 0.964 per %, 95% CI 0.929, 0.998, P = 0.049] was independently associated with New York Heart Association (NYHA) class II–IV heart failure symptoms. Over a median follow-up of 37 (21–62) months, a total of 24 (24%) patients died. Univariable Cox regression analysis demonstrated that LARS [hazard ratio (HR) 0.94 per 1%, 95% CI 0.91, 0.97, P Conclusion In patients with SSc, LARS was independently associated with the presence of NYHA class II–IV heart failure symptoms. Although both LARS and LV GLS were associated with all-cause mortality, only LARS provided incremental value over all evaluated variables known to be prognostically important in patients with SSc. |
| Databáze: | OpenAIRE |
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