Independent Relationship between Serum Osteocalcin and Uric Acid in a Cohort of Apparently Healthy Obese Subjects
| Autor: | Vincenzo Triggiani, Giovanni De Pergola, Federica Gaeta, Edoardo Guastamacchia, Franco Silvestris, Nicola Bartolomeo, Vito Angelo Giagulli, Antonella Petruzzella |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine medicine.medical_specialty Health Status Endocrinology Diabetes and Metabolism Osteocalcin Population Osteoporosis Blood lipids Blood Pressure 030209 endocrinology & metabolism Body Mass Index Bone remodeling 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans Immunology and Allergy education Obesity Metabolically Benign education.field_of_study biology business.industry Middle Aged medicine.disease Lipids Uric Acid 030104 developmental biology Endocrinology chemistry biology.protein Uric acid Female Waist Circumference business Body mass index Biomarkers |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 17 |
| ISSN: | 1871-5303 |
| Popis: | Background It is generally accepted that serum osteocalcin (OC) is a reliable marker of bone formation, while the role of serum uric acid (UA) in bone metabolism is still debated. However, recent studies have shown that endogenous UA within the normal range may exert a positive effect in bone formation by means of its antioxidant role in both sexes. To date, no studies have been carried out in obese subjects aiming to study the relationship between serum OC and UA, given that obesity is considered as a risk factor for osteoporosis and fracture and, at the same time, for cardiovascular events. Objectives Our search purpose was to verify the relationship between endogenous levels of OC and serum UA in a cohort of obese subjects without any metabolic or chronic diseases (i.e. hypertension, renal failure, diabetes mellitus, etc.). Materials and methods One hundred and twenty one obese subjects (93 women and 28 men) were enrolled for this study. Serum OC and UA were assessed and compared with demographic characteristics, clinical and biochemical parameters (age, body mass index (BMI), blood pressure, waist circumference, serum lipids and glycaemia). Results Serum OC was directly and independently correlated with circulating UA in our population of obese subjects, while neither BMI, age, serum lipids, fasting glycaemia nor gender showed a statistically significant correlation with endogenous plasma levels of OC. Conclusion The positive effect determined by serum OC in bone metabolism of our obese subjects might be partly due to the antioxidant properties that normal plasma UA levels exert at bone tissue level. |
| Databáze: | OpenAIRE |
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