Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5

Autor:	Manuela Frese-Schaper, Daniela Miescher, Steffen Frese, Ralph A. Schmid, Anne-Catherine Andres, Beatrice Zumkehr
Rok vydání:	2010
Předmět:	Cancer Research Small interfering RNA Programmed cell death Lung Neoplasms medicine.medical_treatment Apoptosis Receptors Tumor Necrosis Factor Cardiac Glycosides TNF-Related Apoptosis-Inducing Ligand Downregulation and upregulation Carcinoma Non-Small-Cell Lung Cell Line Tumor Antineoplastic Combined Chemotherapy Protocols Medicine Humans RNA Small Interfering Receptor Membrane Glycoproteins business.industry Tumor Necrosis Factor-alpha Drug Synergism 610 Medical sciences Up-Regulation Cardenolides Receptors TNF-Related Apoptosis-Inducing Ligand Cytokine Oncology ddc: 610 Immunology Cancer cell Cancer research Tumor necrosis factor alpha business Apoptosis Regulatory Proteins
Zdroj:	16. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie; 20071004-20071006; Konstanz; DOC07dgtF7 /20100322/
Popis:	Tumor necrosis factor (TNF)-related apoptosisincluding ligand (Apo2L/TRAIL) belongs to the TNF family known to transduce their death signals via cell membrane receptors. Because it has been shown that Apo2L/TRAIL induces apoptosis in tumor cells without or little toxicity to normal cells,[for full text, please go to the a.m. URL] 16. Jahrestagung der Deutschen Gesellschaft für Thoraxchirurgie
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de28f99154105bbf60098c5c642b10b http://nbn-resolving.de/urn:nbn:de:0183-07dgt293 Zobrazit plný text záznamu