ENZYME STUDIES AND NEONATAL BRAIN DAMAGE
| Autor: | B. Dalens, J. L. Viallard, B. Dastugue, E. J. Raynaud |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Pathology Hydroxybutyrate dehydrogenase Brain damage Hydroxybutyrate Dehydrogenase chemistry.chemical_compound Cerebrospinal fluid Double-Blind Method Lactate dehydrogenase Internal medicine Neonatal brain Humans Medicine Prospective Studies Creatine Kinase Transaminases chemistry.chemical_classification Psychomotor learning L-Lactate Dehydrogenase biology business.industry Infant Newborn General Medicine Clinical Enzyme Tests Enzyme Endocrinology chemistry Pediatrics Perinatology and Child Health Apgar Score biology.protein Brain Damage Chronic Creatine kinase Psychomotor Disorders medicine.symptom business |
| Zdroj: | Acta Paediatrica. 70:743-749 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1981.tb05779.x |
| Popis: | Dalens, B, Viallard, JL, Raynaud, EJ, Dastugue, B. (Departement d'Anesthesie-Reanimation, Laboratoire de Biochimie Medicale et Enzymologie, Clinique Medicale Infantile, Hotel-Dieu, Clermont-Ferrand, France). Enzyme studies and neonatal brain damage. Acta Paediatr Scand, 70:743,.–The authors report a double-blind study of 57 full-term newborn infants prospectively subjected to clinical, electroencephalographical, blood and cerebrospinal fluid, and developmental examinations. Four enzymatic activities were measured in blood and CSF: aminotransferase (ASAT), creatine kinase (CK), lactate dehydrogenase (LD) and hydroxybutyrate dehydrogenase (HBD). Close relationships of enzymatic levels with psychomotor outcome are reported. In blood, ASAT and CK seemed to be the most important determinations, allowing threshold-values to be suggested. In CSF, LD and HBD were the determinations the most closely related to psychomotor events at age one. This method seems to be of theoretical as well as practical importance in evaluating neonatal brain injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text