Imbalance Production between Interleukin-1β (IL-1β) and IL-1 Receptor Antagonist (IL-1Ra) in Bronchial Asthma
| Autor: | Hozumi Sano, Chaker N. Adra, X. Q. Mao, Yoko Kataoka, Kaoru Endo, Toshiyuki Aoki, Tadao Enomoto, Julian M. Hopkin, T. Shirakawa, Y. Dake, Takayuki Fukuzumi, Sei Sasaki, M. Kawai, Tetsuji Yamashita, Fumihiko Kurimoto |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Genotype medicine.drug_class Biophysics Inflammation Biochemistry medicine Humans Genetic Testing Allele Molecular Biology Gene Genetic association Asthma business.industry Receptors Interleukin-1 Cell Biology Receptor antagonist medicine.disease Epithelium Phenotype medicine.anatomical_structure Immunology Female medicine.symptom business Airway Interleukin-1 |
| Zdroj: | Biochemical and Biophysical Research Communications. 276:607-612 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.2000.3516 |
| Popis: | Genes of the IL-1 family encode three different peptides, IL-1alpha, IL-1beta, and IL-1Ra, respectively. IL-1 operates through IL-1RI, and is involved in airway inflammation in asthmatic subjects, whereas IL-1Ra appears to be a specific competitive inhibitor of IL-1. All genes are on chromosome 2q12-21 where genomewide searches have identified linkage for asthma. To test whether variants of IL-1 relate to asthma, we conducted a genetic association study in a Japanese population. We show that the A2 allele of IL1RN (encoding IL-1Ra) associates with nonatopic asthma [OR = 5.71, 95% CI: 1.63-19. 8, Pc = 0.007]. Both atopic and nonatopic asthmatics with the A2 allele had significantly lower serum IL-1Ra levels in both types of asthmatics. Peripheral blood cells from asthmatics with A2 alleles, however, produced as much IL-1 as did those with A1 homozygotes. Since Th1 and Th2 cytokines differentially regulate the ratio between IL-1beta and IL-1Ra, these findings suggest that dysregulation of IL-1beta/IL-1Ra, probably due to interaction between epithelium and immuno-competent cells in the airway, is important in asthma inflammation. |
| Databáze: | OpenAIRE |
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