Phytochemical and pharmacological properties of essential oils from Cedrus species
| Autor: | Mona Tannoury, Massimo Tacchini, Alessandra Guerrini, Anake Kijjoa, Gianni Sacchetti, Thomas Efferth, Jihad Abboud, Rosa Tundis, Hassane Makhlouf, Mona Diab-Assaf, Ilaria Lampronti, Samir Medawar, Antoine G. El Samrani, Roberto Gambari, Antoine M. Saab, Jawad Aoun |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Antiproliferative activity
Cedrus atlantica Cedrus deodara Cedrus libani essential oils leukaemia cells Pinaceae Analytical Chemistry Biochemistry Plant Science Organic Chemistry Phytochemicals Anti-Inflammatory Agents 01 natural sciences Cedrus law.invention NO 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents law Oils Volatile Humans Medicinal plants Essential oil Polycyclic Sesquiterpenes Plants Medicinal Traditional medicine biology biology.organism_classification Antineoplastic Agents Phytogenic 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry Phytochemical Drug development 030220 oncology & carcinogenesis Sesquiterpenes |
| Popis: | Natural products frequently exert pharmacological activities. The present review gives an overview of the ethnobotany, phytochemistry and pharmacology of the Cedrus genus, e.g. cytotoxic, spasmolytic immunomodulatory, antiallergic, anti-inflammatory and analgesic activities. Cancer patients frequently seek remedies from traditional medicinal plants that are believed to exert less side effects than conventional therapy with synthetic drugs. A long-lasting goal of anti-cancer and anti-microbial therapy research is to find compounds with reduced side effects compared to currently approved drugs. In this respect, Cedrus species might be of interest. The essential oil isolated from Cedrus libani leaves may bear potential for drug development due to its high concentrations of germacrene D and β-caryophyllene. The essential oils from Cedrus species also show bioactivity against bacteria and viruses. More preclinical analyses (e.g. in vivo experiments) as well as clinical trials are required to evaluate the potential of essential oils from Cedrus species for drug development. |
| Databáze: | OpenAIRE |
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