Risk of seizure relapse after antiepileptic drug withdrawal in adult patients with focal epilepsy
| Autor: | Qingyi Zeng, Huiqin Xu, Ruqian He, Pan Zhu, Rongyuan Zheng, Yixin Bao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Antiepileptic drug Relapse rate Electroencephalography Young Adult 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Recurrence Risk Factors Seizures Internal medicine medicine Humans Registries 030212 general & internal medicine Risk factor Aged medicine.diagnostic_test Adult patients business.industry Middle Aged medicine.disease Withholding Treatment Neurology Anesthesia Anticonvulsants Female Epilepsies Partial Neurology (clinical) business International league against epilepsy 030217 neurology & neurosurgery |
| Zdroj: | Epilepsy & Behavior. 64:233-238 |
| ISSN: | 1525-5050 |
| DOI: | 10.1016/j.yebeh.2016.08.006 |
| Popis: | The objective of this study was to estimate the risk of a seizure relapse and the high-risk period of recurrence after antiepileptic drug (AED) withdrawal and to determine the predictive factors for a seizure relapse in adult patients with focal epilepsy who were seizure-free for more than 2years.Using the Wenzhou Epilepsy Follow-Up Registry Database, 200 adult patients with focal epilepsy were recruited, who were undergoing follow-up, met the inclusion criteria of this study, were seizure-free for more than 2years, began withdrawing between June 2003 and June 2014, and were followed up prospectively for at least 1year or until a seizure relapse. The risk of recurrence and the time to seizure relapse were analyzed by the Kaplan-Meier method, and the predictive factors were identified by the Cox proportional hazard regression model.A total of 99 patients had an unprovoked relapse during the follow-up period. The relapse rate was 49.5%, and each year, the recurrence probability of 12, 24, 36, 48, 60, 72, and 84months after AED withdrawal was 24.0%, 20.4%, 8.3%, 2.7%, 4.6%, 0.97%, and 0.98%, respectively. The two independent risk factors for recurrence after withdrawal in adult patients with focal epilepsy were a longer duration of active epilepsy and a shorter seizure-free period before withdrawal.The high-risk period of a seizure relapse in adult patients with focal epilepsy is the first 2years after withdrawal, and beyond 5years after withdrawal, seizures rarely relapse (relapse rate1%). A seizure-free period for less than 4years before withdrawal is a predictive factor of risk for seizure recurrence after AED withdrawal in adult patients with focal epilepsy. |
| Databáze: | OpenAIRE |
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