Differences in the cytogenetic alteration profiles of diffuse large B-cell lymphoma among Chinese and American patients
| Autor: | Kai Fu, Javeed Iqbal, Bhavana J. Dave, Yan Chen, Wing C. Chan, Xiongzeng Zhu, Warren G. Sanger |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Karyotype Genes myc Biology White People Asian People immune system diseases hemic and lymphatic diseases Genetics medicine Humans Molecular Biology In Situ Hybridization Fluorescence Aged Aged 80 and over Gene Rearrangement medicine.diagnostic_test Incidence Incidence (epidemiology) Germinal center Middle Aged BCL6 medicine.disease Immunohistochemistry Lymphoma DNA-Binding Proteins Immunology Proto-Oncogene Proteins c-bcl-6 Female Lymphoma Large B-Cell Diffuse Diffuse large B-cell lymphoma Fluorescence in situ hybridization |
| Zdroj: | Cancer Genetics. 206:183-190 |
| ISSN: | 2210-7762 |
| DOI: | 10.1016/j.cancergen.2013.05.001 |
| Popis: | To study the similarities and differences of cytogenetic alterations in diffuse large B-cell lymphoma (DLBCL) between Asian and Caucasian patients, we compared the cytogenetic profiles of Chinese and American DLBCL cases by analyzing conventional karyotypes and select fluorescence in situ hybridization (FISH) findings. We used interphase FISH analyses to determine the incidence of the t(14;18) and BCL6 and MYC rearrangements. Immunohistochemical analysis was used to categorize the lymphomas into the germinal center B-cell-like (GCB) or non-GCB-DLBCL subtypes, according to the Hans algorithm. Our data suggested that Chinese patients had cytogenetic profiles for GCB-DLBCL that differed from those of their American counterparts; specifically, the Chinese GCB patients exhibited greater frequencies of BCL6 rearrangements and gains of 1q and 11q but lower incidence of the t(14;18). Non-GCB-DLBCL in both the Chinese and American patients was characterized by recurrent gains of 3/3q and 18/18q. The incidences of both BCL6 rearrangement and t(14;18) were similar in Chinese and American non-GCB-DLBCL cases. |
| Databáze: | OpenAIRE |
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