Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment
| Autor: | Enida Kuric, Karsten Ruscher |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Levodopa medicine.medical_treatment Immunology Pharmacology Proinflammatory cytokine Rats Sprague-Dawley Benserazide Random Allocation Dopamine medicine.artery Lymphopenia medicine Immunology and Allergy Animals Single-Blind Method Stroke business.industry Remission Induction medicine.disease Rats Drug Combinations Treatment Outcome Neurology Anesthesia Middle cerebral artery Neurology (clinical) Lymphocytopenia business Stroke recovery medicine.drug |
| Zdroj: | Journal of neuroimmunology. 269(1-2) |
| ISSN: | 1872-8421 |
| Popis: | Evidences exist that dopamine is involved in T-cell homeostasis. Here, we investigated if daily treatment with levodopa (20mg/kg)/benserazide (15mg/kg) regulates the number of T-cells in the blood of Sprague Dawley rats subjected to transient occlusion of the middle cerebral artery (tMCAO). T-cells and associated inflammatory cytokines were analyzed in the blood one week after tMCAO. Treatment with levodopa/benserazide completely recovered T-helper cell depletion in animals subjected to tMCAO whereas T-cell associated cytokines remained unaffected after stroke, however, cytokines were downregulated in levodopa treated sham operated animals. Together, we demonstrate that dopamine has beneficial effects on poststroke immunodepression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect