Effects of 1,25-Dihydroxyvitamin D3and Retlnolc Acid on the Proliferation and Cell Cycle Phase Distribution of Neuroblastoma SK-N-SH Cells
| Autor: | Goplen Dp, Brackman D, Aksnes L |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Cell Retinoic acid Tretinoin Biology Cell cycle phase Neuroblastoma chemistry.chemical_compound Calcitriol Internal medicine Tumor Cells Cultured medicine Humans Receptor Cell growth Cell Cycle Hematology Cell cycle medicine.disease Molecular biology medicine.anatomical_structure Endocrinology Oncology chemistry Cell culture Pediatrics Perinatology and Child Health Receptors Calcitriol Cell Division |
| Zdroj: | Pediatric Hematology and Oncology. 11:173-179 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.3109/08880019409141653 |
| Popis: | The hormone 1,25-(OH)2D3 has been shown to modulate cell proliferation and induce differentiation in several normal and malignant cell lines. In this work, we examined the effect of the hormone on the neuroblastoma SK-N-SH cell line. The steroid did not influence cell growth and cell cycle distribution, while retinoic acid inhibited proliferation and induced an accumulation of the cells in the G0/G1 phase of the cell cycle. 1,25-(OH)2D3 did not alter cell morphology. The activities of the 1-alpha- and 24-hydroxylases were low and not regulated by the hormone. The level of the total 1,25-(OH)2D3 receptor was low. We conclude that the lack of effect of 1,25-(OH)2D3 on the SK-N-SH cell line is related to the low level of the 1,25-(OH)2D3 receptor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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