The Utility of Segmental Analysis in Cardiac I-123 MIBG SPECT in Parkinson's Disease

Autor:	Soo Hyun Kwon, Su Jin Lee, Joon-Kee Yoon, Jung Han Yoon, Kyung Sook Jo, Dong Hyun Lee, Young-Sil An
Rok vydání:	2015
Předmět:	Parkinson's disease Essential tremor Segmental analysis business.industry Significant difference I 123 mibg Curve analysis Mibg uptake medicine.disease Sympathetic Denervation medicine Radiology Nuclear Medicine and imaging Original Article Nuclear medicine business
Zdroj:	Nuclear medicine and molecular imaging. 49(4)
ISSN:	1869-3474
Popis:	Cardiac images using I-123 metaiodobenzylguanidine (MIBG) are widely used to evaluate cardiac sympathetic denervation in Parkinson’s disease (PD). The aim of this study was to evaluate the utility of segmental analysis on cardiac MIBG SPECT in PD patients. In total, 36 patients with PD (n = 26) or essential tremor (ET, n = 10) who underwent MIBG cardiac SPECT were enrolled. The heart-to-mediastinum (H/M) ratios of MIBG uptake were acquired on planar images. For the segmental analysis of SPECT images, we evaluated the summed defect score (SDS) using a 17-segment model. The diagnostic abilities of H/M ratios and segmental parameters on MIBG SPECT were assessed by ROC curve analysis. The H/M ratios were significantly lower in PD than in ET patients (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddad6a5f2c486bd2500a25ed54adf9e https://pubmed.ncbi.nlm.nih.gov/26550049 Zobrazit plný text záznamu Full text from SpringerLink