Differential molecular profiling between skin carcinomas reveals four newly reported genes potentially implicated in squamous cell carcinoma development
| Autor: | Jerome Cuminet, Delphine Compan, Marjorie Chazal, Gisele Delestaing, Claude Lalou, Louis Dubertret, Claire Marionnet, Olivier Verola, C. Vilmer, Karine Mollier, Nicole Basset-Seguin |
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| Rok vydání: | 2003 |
| Předmět: |
Cancer Research
Skin Neoplasms RhoC Nerve Tissue Proteins Biology Bioinformatics Complementary DNA Genetics Carcinoma medicine Humans Basal cell carcinoma RNA Messenger neoplasms Molecular Biology Gene Regulation of gene expression Messenger RNA integumentary system Gene Expression Profiling medicine.disease Gene expression profiling Gene Expression Regulation Neoplastic stomatognathic diseases Cell Transformation Neoplastic Cancer research biology.protein Carcinoma Squamous Cell |
| Zdroj: | Oncogene. 22(22) |
| ISSN: | 0950-9232 |
| Popis: | Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are skin tumors with different invasive potential. In this work, we analysed mRNA differential expression between seven BCC and five SCC and their normal skin counterparts using 1176 cDNA macroarrays and verification by RT-PCR to identify genes modulated in each tumor type. We identified 37 genes commonly modulated in both tumors and four genes specifically modulated in SCC. Among these latter RhoC and EMMPRIN genes seem to be of particular interest and could participate in SCC aggressivity. |
| Databáze: | OpenAIRE |
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