Full-length HIV-1 immunogens induce greater T lymphocyte responses to conserved epitopes than conserved-region-only HIV-1 immunogens in monkeys
| Autor: | Bette T. Korber, Kathryn E. Stephenson, Nathaniel L. Simmons, Kaitlin M. Smith, Dan H. Barouch, James J. Szinger, Adam J. SanMiguel |
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| Rok vydání: | 2012 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
biology business.industry viruses Immunogenicity Human immunodeficiency virus (HIV) virus diseases T lymphocyte medicine.disease_cause Virology Epitope Bivalent (genetics) Vaccination Infectious Diseases Immune system Immunology biology.protein medicine Oral Presentation Antibody lcsh:RC581-607 business |
| Zdroj: | Retrovirology, Vol 9, Iss Suppl 2, p O70 (2012) Retrovirology |
| ISSN: | 1742-4690 |
| DOI: | 10.1186/1742-4690-9-s2-o70 |
| Popis: | Background A global HIV-1 vaccine will need to induce broadly reactive immune responses against conserved HIV-1 regions. It is currently unclear how best to elicit these responses by vaccination. We therefore compared the immunogenicity of a bivalent full-length HIV-1 Gag/Pol/Env mosaic vaccine, a trivalent full-length HIV-1 Gag/Pol/Env mosaic vaccine, and a bivalent mosaic vaccine containing only conserved HIV-1 Gag/Pol/Env epitopes in rhesus monkeys. |
| Databáze: | OpenAIRE |
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