Prevalence and risk factors for Human T-Lymphotropic Virus Type 1 (HTLV-1) among maintenance hemodialysis patients
| Autor: | Maria Auxiliadora Penalva, Edgar M. Carvalho, Paulo Novis Rocha, Antonio Alberto Lopes, Márcia Tereza Silva Martins, Rilma F. S. Santos, Angiolina Campos Kraychete, Gildasio Carvalho da Conceicao |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty viruses Population 030232 urology & nephrology Comorbidity Human T-lymphotropic virus Asymptomatic 03 medical and health sciences 0302 clinical medicine Renal Dialysis Risk Factors Internal medicine Tropical spastic paraparesis Prevalence medicine Humans Outpatient clinic Blood Transfusion 030212 general & internal medicine education Aged Human T-lymphotropic virus 1 education.field_of_study biology business.industry Hepatitis C Odds ratio Chronic Kidney 47 Disease Middle Aged Hepatitis B medicine.disease biology.organism_classification HTLV-I Infections Causality Treatment Outcome Nephrology Hemodialysis Kidney Failure Chronic Female medicine.symptom business Brazil Research Article Human T-Lymphotropic Virus Type 1 |
| Zdroj: | BMC Nephrology |
| ISSN: | 1471-2369 |
| DOI: | 10.1186/s12882-017-0484-y |
| Popis: | Background Infection with the human T-cell lymphotropic virus type 1 (HTLV-1), although asymptomatic in most cases, can lead to potentially grave consequences, such as adult T-cell leukemia-lymphoma and HTLV-1-associated myelopathy / tropical spastic paraparesis. Its prevalence varies widely across different populations and geographic regions. A population-based study in the city of Salvador, located in the Northeast region of Brazil, showed an overall prevalence of HTLV-1 seropositivity of 1.7%. Blood borne virus infections are recognized as important hazards for patients and staff in maintenance hemodialysis (MHD) units but most studies focus on hepatitis B, hepatitis C and human immunodeficiency viruses. There are scarce data about HTLV-1 infection in the MHD population. We aimed to determine the prevalence and risk factors for HTLV-1 infection among MHD patients in the city of Salvador-Bahia, Brazil. Methods We conducted a multi-center, cross-sectional study nested in a prospective cohort of MHD patients enrolled from four outpatient clinics. HTLV-1 screening was performed with ELISA and positive cases were confirmed by Western Blot. Factors associated with HTLV-1 seropositivity were identified by multivariable logistic regression. Results 605 patients were included in the study. The overall prevalence of HTLV-1 infection was 2.48% (15/605), which was similar to that of hepatitis B [1.98% (12/605)] and C [3.14% (19/605)] viruses in our sample. HTLV-1 seropositivity was positively associated with age [prevalence odds ratio (POR) 1.04; 95% confidence interval (CI) 1.01–1.08], unmarried status (POR 3.65; 95% CI 1.13–11.65), and history of blood transfusion (POR 3.35; 95% CI 1.01–11.13). Conclusions The overall prevalence of HTLV-1 infection in a sample of MHD patients was similar to that of other viral infections, such as hepatitis B and C. Our data revealed that MHD patients who are older, unmarried or who have received blood transfusions are at higher risk for HTLV-1 infection. |
| Databáze: | OpenAIRE |
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