ALLOGENEIC HEMOPOIETIC STEM CELL TRANSPLANTATION FOR CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA IN SECOND COMPLETE REMISSION—Similar Outcomes After Matched Related and Unrelated Donor Transplant: A Study of the Spanish Working Party for Blood and Marrow Transplantation in Children (Getmon)

Autor:	Maldonado Ms, Isabel Badell, Muñoz A, J. M. Perez-Hurtado, M. E. Gonzalez-Valentin, Amparo Verdeguer, Miguel Angel Diaz, A. Martínez, E Bureo, Cristina Diaz-Heredia, Pedro Gómez, Rafael Fernández-Delgado
Rok vydání:	2008
Předmět:	Male medicine.medical_specialty Transplantation Conditioning Adolescent medicine.medical_treatment Graft vs Host Disease Hematopoietic stem cell transplantation Quality of life Recurrence Unrelated Donor Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Transplantation Homologous Child Survival rate Childhood Acute Lymphoblastic Leukemia business.industry Marrow transplantation Remission Induction Hematopoietic Stem Cell Transplantation Infant Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma Combined Modality Therapy Surgery Survival Rate Transplantation Treatment Outcome Oncology Child Preschool Pediatrics Perinatology and Child Health Quality of Life Female business
Zdroj:	Pediatric Hematology and Oncology. 25:245-259
ISSN:	1521-0669 0888-0018
DOI:	10.1080/08880010802016557
Popis:	The authors report the results of 58 children with ALL in 2CR after related (n = 31) or unrelated (n = 27) AHSCT. Characteristics at diagnosis and initial and after relapse antileukemic treatment were similar in the related donor (RD) and the unrelated donor (UD) groups. Conditioning consisted of TBI/CY +/- VP-16 for patients > or = 3 years old (n = 43) and Bu/CY for the rest. Median recipient age was 8 years (range 1-17) in the RD and 9 years (range 3-14) in the UD group. Median follow-up was 54 months (range 24-80) and 52 months (range 22-85) in the RD and the UD groups repectively. The 5-year EFS probability was 43 +/- 9% for the RD group and 36 +/- 9% in the UD group (p = .25). The transplant-related mortality was 16% in the RD and 37% in the UD group (p = .016). In the RD group 36.7% of patients relapsed versus 18.6% in the UD group (p = .05). GvHD associated with organ failure or infection caused most of the transplant-related deaths in both groups. Survivor quality of life for both groups was good (Lansky score < or = 90).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd319ac5e45db71121ec3af7e2d39ad https://doi.org/10.1080/08880010802016557 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.