Clinical significance of the ABCB1 and ABCG2 gene expression levels in acute lymphoblastic leukemia
| Autor: | J. Collazo Jaloma, A. Martínez Tovar, C.O. Ramos Peñafiel, I. Olarte Carrillo, F. Centeno Cruz, K. Nacho Vargas, J. J. Kassack Ipiña, E. Rozen Fuller, E. Miranda Peralta, E. Garrido Guerrero |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B Adolescent Abcg2 Disease Drug resistance Disease-Free Survival law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine medicine ATP Binding Cassette Transporter Subfamily G Member 2 Humans Clinical significance Survival rate Polymerase chain reaction biology ABCG2 Gene Hematology Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma Neoplasm Proteins Gene Expression Regulation Neoplastic Survival Rate Exact test 030104 developmental biology 030220 oncology & carcinogenesis Immunology biology.protein Female |
| Zdroj: | Hematology. 22:286-291 |
| ISSN: | 1607-8454 |
| Popis: | Acute lymphoblastic leukemia (ALL) is a clonal disease that accounts for 20% of acute leukemias in adults. A high percentage of adult patients (ranging from 70 to 80%) reach complete remission; however, the 5-year survival rate is only 20-40%. One of the main obstacles to treatment success is the drug resistance of leukemic cells. Therefore, our research group analyzed the ABCB1 and ABCG2 gene expression levels in 61 patients diagnosed with ALL and assessed whether the levels affected the clinical parameters and 40-month survival rate.The ABCB1 and ABCG2 gene expression levels were analyzed using real-time polymerase chain reaction in 61 patients diagnosed with ALL and 99 healthy donors as controls. The association between ABCB1 and ABCG2 gene expression levels and clinical variables was determined using the Chi-square test and Fisher's exact test. Overall survival (OS) was determined using the Kaplan-Meier method.The results showed high ABCB1 and ABCG2 gene levels, which were 4.5 and 2.3 times the levels of healthy donors, respectively. A total of 52% of the study patients expressed high ABCB1 levels and were significantly associated with the high-risk patient group and a decreased 40-month survival rate of 78%. Only 49% of the patients expressed high ABCG2 gene levels. No association was found between the clinical parameters and the ABCG2 gene expression levels.Early detection of ABCB1 gene expression levels could be important for the diagnosis and monitoring of ALL patients. |
| Databáze: | OpenAIRE |
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