Antiinflammatory fluoroalkanesulfonanilides. 3. Other fluoroalkanesulfonamido diaryl systems
| Autor: | J. K. Harrington, G. G. I. Moore, K. F. Swingle |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Sulfonamides
Hydrocarbons Fluorinated Chemistry Anti-Inflammatory Agents Molecular Conformation Stereoisomerism Carrageenan Ring (chemistry) Medicinal chemistry Rats Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Phenylbutazone medicine Animals Edema Molecular Medicine Single bond Female medicine.drug |
| Zdroj: | Journal of Medicinal Chemistry. 18:386-391 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00238a013 |
| Popis: | A series of isosteres of 3-benzoyltrifluoromethanesulfonanilide involving alternatives to the carbonyl linking group was synthesized and screened for antiinflammatory activity in the carrageenan rat paw edema test. The systems examined were of the type m-CF3SO2NH-C6H4-X-C6H5, where X was -CROH-, -CHR-, -CH(OH)CH2-, -COCH2-, -CH2CO-, greater than C equal to CR2, -CR equal to CH, -C identical to C-, -CH2CH2-, CONH-, -NR-, -O-, -S(O)n- (n equal to 0,1,2), and carbon-carbon single bond. Many ortho and para derivatives were also tested. Several of these new trifluoromethanesulfonanilides proved equipotent with phenylbutazone. The effects on the anticarrageenan activity of both the nature and ring position of X are discussed. |
| Databáze: | OpenAIRE |
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