Circulating anandamide and blood pressure in patients with obstructive sleep apnea
| Autor: | Reiner Jumpertz, Tobias Wiesner, Pal Pacher, Sandor Batkai, Jens Jordan, Matthias Blüher, George Kunos, Judy Harvey-White, Hubertus Wirtz, Stefan Engeli, Andrea Bosse-Henck, Michael Stumvoll |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Cannabinoid receptor Polyunsaturated Alkamides Physiology medicine.medical_treatment Blood Pressure Arachidonic Acids Insulin resistance Risk Factors Internal medicine Internal Medicine medicine Humans Obesity Aged Sleep Apnea Obstructive business.industry Insulin Sleep apnea Apnea Middle Aged medicine.disease Obstructive sleep apnea Cross-Sectional Studies Endocrinology Blood pressure Diabetes Mellitus Type 2 Cardiovascular Diseases Hypertension Female Insulin Resistance medicine.symptom Cardiology and Cardiovascular Medicine business Hypopnea Biomarkers Endocannabinoids |
| Zdroj: | Journal of Hypertension. 30:2345-2351 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/hjh.0b013e3283591595 |
| Popis: | Objective: Obstructive sleep apnea chronically increases blood pressure through sympathetic nervous system activation. In animals, hypertension and sympathetic activity are restrained by cannabinoid receptor activation. Therefore, we hypothesized that increased blood pressure in patients with obstructive sleep apnea is associated with increased circulating endocannabinoid concentrations. Methods: Arterial oxygen saturation and apnea/hypopnea episodes were recorded in 29 patients with normal glucose tolerance, 26 patients with type 2 diabetes mellitus, and 21 patients obese subjects without sleep apnea. We determined seated blood pressure, insulin, glucose, and high-sensitive C-reactive protein in the morning, and insulin sensitivity by euglycemic-hyperinsulinemic clamp the next day. Anandamide, the sum of 1-arachidonoylglycerol and 2-arachidonoylglycerol, and oleoylethanolamide were measured in plasma by liquid chromatography-tandem mass spectrometry. Results: Endocannabinoid concentrations in sleep apnea patients were increased compared to obese individuals without disordered nocturnal breathing. Correction for variables of obesity and insulin resistance almost completely abrogated this difference in endocannabinoids. Anandamide strongly correlated with blood pressure in sleep apnea patients (r ¼0.60 for SBP and r ¼0.58 for DBP, P |
| Databáze: | OpenAIRE |
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