Teratogenic potential of tribenoside, a drug for the treatment of haemorrhoids and varicose veins--a population-based case--control study
| Autor: | Andrew E. Czeizel, Tamás Kubicsek, Zoltán Kazy |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Administration Oral Toxicology Tribenoside Hemorrhoids Risk Assessment Varicose Veins Young Adult Pregnancy Risk Factors Varicose veins medicine Odds Ratio Humans Glycosides Retrospective Studies Hungary Vascular disease Obstetrics business.industry Anti-Inflammatory Agents Non-Steroidal Abnormalities Drug-Induced Retrospective cohort study Odds ratio medicine.disease Teratology Surgery Pregnancy Complications Logistic Models Case-Control Studies Gestation Female medicine.symptom business medicine.drug Hydrocephalus |
| Zdroj: | Reproductive toxicology (Elmsford, N.Y.). 31(4) |
| ISSN: | 1873-1708 |
| Popis: | Tribenoside is used for the treatment of haemorrhoids and varicose veins, frequently in pregnant women as well, but published data regarding its possible teratogenic effect are not available. Thus the risk of congenital abnormalities (CAs) was estimated in cases of pregnant women with oral tribenoside treatment (TT) in the Hungarian Case-Control Surveillance System of Congenital Abnormalities. Of 22,843 cases with CA, 174 (0.76%), while of 38,151 matched controls without CA, 285 (0.75%) were born to mothers with TT. There was no higher risk for total CAs after TT during any time of pregnancy but congenital hydrocephaly had a higher risk after medically recorded TT in the second and/or third month of pregnancy, i.e. critical period of this CA. In conclusion TT in pregnant women associated with a higher risk of congenital hydrocephalus in their children, however, this finding is based on only 4 cases therefore requires further confirmation in future studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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