Human milk extracellular vesicles target nodes in interconnected signalling pathways that enhance oral epithelial barrier function and dampen immune responses

Autor: Zonneveld, Marijke I, van Herwijnen, Martijn J C, Fernandez-Gutierrez, Marcela M, Giovanazzi, Alberta, de Groot, Anne Marit, Kleinjan, Marije, van Capel, Toni M M, Sijts, Alice J A M, Taams, Leonie S, Garssen, Johan, de Jong, Esther C, Kleerebezem, Michiel, Nolte-'t Hoen, Esther N M, Redegeld, Frank A, Wauben, Marca H M, Sub Immunopharmacology, Celbiologie, dB&C I&I, LS Immunologie, Immunologie, dI&I RA-I&I I&I, Afd Pharmacology, LS IRAS Tox RTX (Reprod.en ontw.toxic.), Pharmacology
Přispěvatelé: Sub Immunopharmacology, Celbiologie, dB&C I&I, LS Immunologie, Immunologie, dI&I RA-I&I I&I, Afd Pharmacology, LS IRAS Tox RTX (Reprod.en ontw.toxic.), Pharmacology, Medical Biology, AII - Inflammatory diseases, Experimental Immunology
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
T-Lymphocytes
p38 Mitogen-Activated Protein Kinases
0302 clinical medicine
fluids and secretions
Receptor
Research Articles
2. Zero hunger
0303 health sciences
Chemistry
food and beverages
human milk
Cell migration
Cell biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
TLR modulation
breast milk
Female
oral cavity
extracellular vesicles
Intracellular
Research Article
Adult
Cell type
Histology
Endosome
MAP Kinase Signaling System
T cell
exosomes
Breast milk
T cell modulation
Cell Line
03 medical and health sciences
Extracellular Vesicles
Immune system
medicine
Humans
Host-Microbe Interactomics
VLAG
030304 developmental biology
immune modulation
QH573-671
Milk
Human
Mouth Mucosa
Cell Biology
immune system development
Microvesicles
Toll-Like Receptor 3
030104 developmental biology
Toll-Like Receptor 9
TLR3
WIAS
gastrointestinal tract
Cytology
Zdroj: Journal of Extracellular Vesicles
Journal of extracellular vesicles, 10(5):e12071. Taylor and Francis Ltd.
Journal of Extracellular Vesicles 10 (2021) 5
Journal of Extracellular Vesicles, 10(5)
Journal of Extracellular Vesicles, 10(5), 1. Co-Action Publishing
Journal of Extracellular Vesicles, Vol 10, Iss 5, Pp n/a-n/a (2021)
ISSN: 2001-3078
Popis: Maternal milk is nature’s first functional food. It plays a crucial role in the development of the infant’s gastrointestinal (GI) tract and the immune system. Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer enclosed vesicles released by cells for intercellular communication and are a component of milk. Recently, we discovered that human milk EVs contain a unique proteome compared to other milk components. Here, we show that physiological concentrations of milk EVs support epithelial barrier function by increasing cell migration via the p38 MAPK pathway. Additionally, milk EVs inhibit agonist-induced activation of endosomal Toll like receptors TLR3 and TLR9. Furthermore, milk EVs directly inhibit activation of CD4+ T cells by temporarily suppressing T cell activation without inducing tolerance. We show that milk EV proteins target key hotspots of signalling networks that can modulate cellular processes in various cell types of the GI tract.
Databáze: OpenAIRE
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