Beam characterization and feasibility study for a small animal irradiation platform at clinical proton therapy facilities
| Autor: | Christian Skou Søndergaard, Katia Parodi, M Hillbrand, M. Vidal, Indra Yohannes, Sairos Safai, Cai Grau, Joel Herault, Enrico Verroi, Marco Pinto, Jacobus M. Schippers, Jörg Schreiber, Francesco Tommasino, Neeraj Kurichiyanil, Sonja Gerlach, Marco Schwarz, Per Rugaard Poulsen |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
medicine.medical_treatment pre-clinical research Radiation small animal irradiation Collimated light beam manipulation proton therapy 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Optics medicine Proton Therapy Animals Radiology Nuclear Medicine and imaging Thermal emittance Irradiation Radiometry Proton therapy Particle therapy Radiological and Ultrasound Technology business.industry Radiotherapy Planning Computer-Assisted Radiotherapy Dosage Beamline 030220 oncology & carcinogenesis Feasibility Studies DOSE CALCULATION SCANNED PROTON business Beam (structure) Synchrotrons Radiotherapy Image-Guided |
| Zdroj: | Physics in Medicine & Biology Gerlach, S, Pinto, M, Kurichiyanil, N, Grau, C, Hérault, J, Hillbrand, M, Poulsen, P R, Safai, S, Schippers, J M, Schwarz, M, S ndergaard, C S, Tommasino, F, Verroi, E, Vidal, M, Yohannes, I, Schreiber, J & Parodi, K 2020, ' Beam characterization and feasibility study for a small animal irradiation platform at clinical proton therapy facilities ', Physics in Medicine and Biology, vol. 65, no. 24, 245045 . https://doi.org/10.1088/1361-6560/abc832 |
| ISSN: | 1361-6560 |
| DOI: | 10.1088/1361-6560/abc832 |
| Popis: | A deeper understanding of biological mechanisms to promote more efficient treatment strategies in proton therapy demands advances in preclinical radiation research. However this is often limited by insufficient availability of adequate infrastructures for precision image guided small animal proton irradiation. The project SIRMIO aims at filling this gap by developing a portable image-guided research platform for small animal irradiation, to be used at clinical facilities and allowing for a precision similar to a clinical treatment, when scaled down to the small animal size. This work investigates the achievable dosimetric properties of different lowest energy clinical proton therapy beams, manipulated by a dedicated portable beamline including active focusing after initial beam energy degradation and collimation. By measuring the lateral beam size in air close to the beam nozzle exit and the laterally integrated depth dose in water, an analytical beam model based on the beam parameters of the clinical beam at the Rinecker Proton Therapy Center was created for the lowest available clinical beam energy. The same approach was then applied to estimate the lowest energy beam model of different proton therapy facilities, Paul Scherrer Institute, Centre Antoine Lacassagne, Trento Proton Therapy Centre and the Danish Centre for Particle Therapy, based on their available beam commissioning data. This comparison indicated similar beam properties for all investigated sites, with emittance values of a few tens of mm·mrad. Finally, starting from these beam models, we simulated propagation through a novel beamline designed to manipulate the beam energy and size for precise small animal irradiation, and evaluated the resulting dosimetric properties in water. For all investigated initial clinical beams, similar dosimetric results suitable for small animal irradiation were found. This work supports the feasibility of the proposed SIRMIO beamline, promising suitable beam characteristics to allow for precise preclinical irradiation at clinical treatment facilities. |
| Databáze: | OpenAIRE |
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