Ovarian failure induced by 4-vinylcyclohexene diepoxide worsens the autonomic cardiovascular response to chronic unpredictable stress in rats
| Autor: | Domitila A. Huber, Janete Aparecida Anselmo-Franci, Tamires Gregorio, Bruna B. Simas, Fernanda B. Lima, Flaviano Lorenzon, Cilene Lino de Oliveira |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Vinyl Compounds Stress exposure Estrous Cycle Primary Ovarian Insufficiency Baroreflex Autonomic Nervous System Cardiovascular System 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Ovarian function Ovarian Follicle Internal medicine Cyclohexenes medicine Animals Rats Wistar General Pharmacology Toxicology and Pharmaceutics 4 vinylcyclohexene diepoxide business.industry Ovary Ovarian failure General Medicine Plasma levels medicine.disease Perimenopause Rats Menopause Disease Models Animal 030104 developmental biology Endocrinology Female business Stress Psychological Hormone |
| Zdroj: | Life Sciences. 226:130-139 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2019.04.007 |
| Popis: | Aims After menopause, women are more responsive to stress and more prone to exhibit hypertension, which elevates the risk of cardiac diseases. This vulnerability is due, in part, to the decline of ovarian steroids plasma levels. The 4-vinylciclohexane diepoxide (VCD) causes a gradual depletion of ovarian follicles causing loss of the normal ovarian function and a hormonal profile comparable to menopause in humans. We aimed to verify whether the ovarian failure (OF) worsens the cardiovascular autonomic response to stress. Main methods Rats were treated with VCD (160 mg/kg) or oil for 15 days, exposed to chronic unpredictable stress (CUS) for 10 days and studied 80 and 180 days after VCD treatment. Key findings 80 days after VCD-treatment, stressed rats showed increased sympathetic nerve activity, reduced parasympathetic activity and an increase in the overall spontaneous baroreflex sensitivity (BRS). 180 days after VCD treatment, BRS was impaired and the vascular sympathetic activity was increased, independently of stress exposure. Significance Neither 80 nor 180 days after the onset of VCD-treatment the hypertensive effects of stress were enhanced in rats. However, OF led to a worsening on different aspects of the cardiovascular response to stress, which can cause cardiovascular complications when associated with ovarian aging. |
| Databáze: | OpenAIRE |
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