[Flow cytometric DNA analysis and MR imaging of salivary gland tumors]
| Autor: | Kenji Mitani, Shigeru Okamoto, Arata Horii, Takeshi Kubo, Kenji Hattori, Yuichiro Honjo, Junichi Yoshida, Masahide Sakai, Shodayu Takashima |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Pathology Adenoma Adenoma Pleomorphic Aneuploidy Flow cytometry chemistry.chemical_compound medicine Humans Retrospective Studies medicine.diagnostic_test Salivary gland business.industry Cell Cycle Magnetic resonance imaging DNA Neoplasm medicine.disease Adenolymphoma Flow Cytometry Salivary Gland Neoplasms Mr imaging Magnetic Resonance Imaging medicine.anatomical_structure Ki-67 Antigen Otorhinolaryngology chemistry Histopathology business Nuclear medicine DNA |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0030-6622 |
| Popis: | We correlated the histopathology of 32 cases of salivary gland tumors with MR imaging and flow cytometric DNA analysis. All malignant tumors were invasive and/or had an ill-defined margin. Fifty-seven percent of the pleomorphic adenomas were shown as a high signal intensity area on T2 weighted images. Fifty-six percent of Warthin tumors were shown as a low or iso signal intensity area on T2 weighted images associated with the cystic portion. Sixty-seven percent of malignant tumors were characterized by DNA aneuploidy and/or a total percentage of the S-phase fraction plus the G2 + M fraction higher than 10%. It was less than 10% and the Ki-67 positive fraction was higher than 20% in all pleomorphic adenomas. The Ki-67 positive fraction was less than 20% in 78% of Warthin tumors. The histopathology of all malignant tumors, 86% of the pleomorphic adenomas, and 89% of Warthin tumors was correctly predicted by the combination of MR images and flow cytometry. We suggest that the MR images combined with flow cytometric analysis of fine needle aspiration-derived materials is useful in the pre-operative histopathologic diagnosis of salivary gland tumors. |
| Databáze: | OpenAIRE |
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