Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug accumulation in solid tumor xenografts
| Autor: | Ande Bao, Gary D. Fullerton, Ivan L. Cameron, Beth A. Goins, Xiangpeng Zheng, Victoria Frohlich, Cristina Santoyo |
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| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Toxicology Rats Nude Extracellular fluid medicine Animals Distribution (pharmacology) Pharmacology (medical) Doxorubicin Radionuclide Imaging Sodium Pertechnetate Tc 99m Tomography Emission-Computed Single-Photon Pharmacology Liposome Antibiotics Antineoplastic Dose-Response Relationship Drug Chemistry Extracellular Fluid Ultrasonography Doppler medicine.disease Xenograft Model Antitumor Assays Head and neck squamous-cell carcinoma Rats Dose–response relationship Matrix Metalloproteinase 8 Oncology Head and Neck Neoplasms Liposomes Drug delivery Autoradiography Female Histopathology Radiopharmaceuticals medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 67:173-182 |
| ISSN: | 1432-0843 0344-5704 |
| DOI: | 10.1007/s00280-010-1305-1 |
| Popis: | To investigate the effect of intratumoral administration of collagenase-2 on liposomal drug accumulation and diffusion in solid tumor xenografts. Correlation between tumor interstitial fluid pressure (IFP) and tumor physiological properties (size and vessel fraction by B-mode and Doppler ultrasound, respectively) was determined. IFP response to intravenous or intratumoral collagenase-2 (0.1%) treatment was compared with intratumoral deactivated collagenase-2. To evaluate drug accumulation and diffusion, technetium-99 m-(99mTc)-liposomal doxorubicin (Doxil™) was intravenously injected after collagenase-2 (0.1 and 0.5%, respectively) treatment, and planar scintigraphic images acquired and percentage of the injected dose per gram tissue calculated. Subsequently, tumors were subjected to autoradiography and histopathology. IFP in two-week-old head and neck squamous cell carcinoma xenografts was 18 ± 3.7 mmHg and not correlated to the tumor size but had reverse correlation with the vessel fraction (r = −0.91, P |
| Databáze: | OpenAIRE |
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