Palladium-Catalyzed Remote Hydro-Oxygenation of Internal Alkenes: An Efficient Access to Primary Alcohols

Autor:	Xiang Li, Xintuo Yang, Pinhong Chen, Guosheng Liu
Rok vydání:	2022
Předmět:	Colloid and Surface Chemistry General Chemistry Biochemistry Catalysis
Zdroj:	Journal of the American Chemical Society. 144:22877-22883
ISSN:	1520-5126 0002-7863
DOI:	10.1021/jacs.2c11428
Popis:	As a general method for the synthesis of alcohols, the direct oxygenation of alkenes is difficult to afford linear alcohols. Herein, we communicate the remote hydro-oxygenation of alkenes under palladium catalysis, in which both terminal and internal alkenes are suitable to yield the corresponding linear alcohols efficiently. A compatible SelectFluor/silane redox system plays an essential role for the excellent chemo- and regioselectivities. The reaction features a broad substrate scope and excellent functional group compatibility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc2a986bfb2172271a21349bac04f3f https://doi.org/10.1021/jacs.2c11428 Zobrazit plný text záznamu