Whole genome association analysis of treatment response in obsessive-compulsive disorder

Autor: Manuel Mattheisen, Oscar J. Bienvenu, Youfa Wang, James A. Knowles, Yin Yao Shugart, Kathleen D. Askland, John Piacentini, Erika L. Nurmi, Fernando S. Goes, Daniel A. Geller, Abby J. Fyer, Ann E. Pulver, Brion S. Maher, Christoph Lange, Benjamin D. Greenberg, Nicole C.R. McLaughlin, Gerald Nestadt, Jack Samuels, D. L. Murphy, Yun Zhu, Hai-De Qin, Kung-Yee Liang, Marco A. Grados, James T. McCracken, David Valle, S. A. Rasmussen, Mark A. Riddle, S. E. Stewart, Bernadette Cullen, David L. Pauls
Jazyk: angličtina
Rok vydání: 2015
Předmět:
0301 basic medicine
False discovery rate
Proband
Adult
Male
Linkage disequilibrium
Obsessive-Compulsive Disorder
Adolescent
Genome-wide association study
Single-nucleotide polymorphism
Genome Wide Association Study
Polymorphism
Single Nucleotide
Article
Serotonin Reuptake Inhibitors
Linkage Disequilibrium
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Polymorphism (computer science)
Genetic variation
SNP
Humans
Genetic Predisposition to Disease
Child
Molecular Biology
Aged
Genetics
Genetic Variation
Membrane Proteins
Middle Aged
3. Good health
Psychiatry and Mental health
030104 developmental biology
Treatment Outcome
Pharmacogenetics
Female
Self Report
Psychology
030217 neurology & neurosurgery
Selective Serotonin Reuptake Inhibitors
Genome-Wide Association Study
Zdroj: Molecular psychiatry
Qin, H, Samuels, J F, Wang, Y, Zhu, Y, Grados, M A, Riddle, M A, Greenberg, B D, Knowles, J A, Fyer, A J, McCracken, J T, Murphy, D L, Rasmussen, S A, Cullen, B A, Piacentini, J, Geller, D, Stewart, S E, Pauls, D, Bienvenu, O J, Goes, F S, Maher, B, Pulver, A E, Valle, D, Mattheisen, M, McLaughlin, N C, Liang, K-Y, Nurmi, E L, Askland, K D, Nestadt, G & Shugart, Y Y 2015, ' Whole-genome association analysis of treatment response in obsessive-compulsive disorder ', Molecular Psychiatry . https://doi.org/10.1038/mp.2015.32
ISSN: 1476-5578
1359-4184
1716-2912
DOI: 10.1038/mp.2015.32
Popis: Up to 30% of patients with obsessive-compulsive disorder (OCD) exhibit an inadequate response to serotonin reuptake inhibitors (SRIs). To date, genetic predictors of OCD treatment response have not been systematically investigated using genome-wide association study (GWAS). To identify specific genetic variations potentially influencing SRI response, we conducted a GWAS study in 804 OCD patients with information on SRI response. SRI response was classified as 'response' (n=514) or 'non-response' (n=290), based on self-report. We used the more powerful Quasi-Likelihood Score Test (the MQLS test) to conduct a genome-wide association test correcting for relatedness, and then used an adjusted logistic model to evaluate the effect size of the variants in probands. The top single-nucleotide polymorphism (SNP) was rs17162912 (P=1.76 × 10(-8)), which is near the DISP1 gene on 1q41-q42, a microdeletion region implicated in neurological development. The other six SNPs showing suggestive evidence of association (P
Databáze: OpenAIRE
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