Serum 'Angiotensinase activity' and female steroidal hormones
| Autor: | Lubash Gd, Bard Rh, Kline Ja |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Adult
Electrophoresis Male medicine.medical_specialty Adolescent medicine.medical_treatment Population Ethinyl Estradiol Plasma renin activity Preeclampsia chemistry.chemical_compound Pre-Eclampsia Pregnancy Internal medicine Endopeptidases Renin Medicine Animals Humans education Gonadal Steroid Hormones education.field_of_study biology Progestogen business.industry Angiotensin II Uterus Dimethisterone Alanine Transaminase Starch General Medicine medicine.disease Amides Enzyme assay Rats Blood pressure Endocrinology Ethisterone chemistry biology.protein Biological Assay Female Rabbits business Gels Contraceptives Oral |
| Zdroj: | The American journal of the medical sciences. 257(3) |
| ISSN: | 0002-9629 |
| Popis: | Angiotensinase activity was measured in the third trimester of normal pregnancy (15) and preeclampsia (6) in women taking taking contraceptive pills (Oracon) (21) in males who also took these pills (3) and in serum and uterine tissue from pregnant and nonpregnant rabbits serving as controls. The findings of decreased angiotensin II amide survival and increased alpha-L-aspartyl-beta-naphthylamide hydrolysis in women during the third trimester of normal pregnancy suggests a possible relationship between serum angiotensinase activity and female steroidal hormones. Confirmatory evidence was provided by similar results with the latter substrate in women receiving contraceptive pills. Synthetic estrogen but not progestogen induced increased serum naphthylamidase activity in male volunteers. Starch gel electrophoresis was similar in normal women pregnant women and women on contraceptives in the patterns of proteins and this enzyme activity. Electrophoretic studies of enzyme activity in serum and uterine tissue extracts were not demonstrated in the electrophoresis studies and increased enzyme activity in human subjects could not be correlated with plasma renin activity blood pressure or liver cell damage it seems likely that the increased aspartic naphthylamidase hydrolysis is part of a nonspecific naphthylamidase increase induced by estrogens.(Authors modified) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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