Multiple potential roles of thymosin β4 in the growth and development of hair follicles
| Autor: | Jianlong Yuan, Ri‐Na Sha, Bai Dai, Dongjun Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Organogenesis growth Reviews Endogeny Review Biology Hair growth 03 medical and health sciences Structure-Activity Relationship 0302 clinical medicine medicine Animals Humans Progenitor cell Thymosin β4 development integumentary system hair follicle Cell Biology Hair follicle Cell biology Thymosin 030104 developmental biology medicine.anatomical_structure Dermal papillae Gene Expression Regulation 030220 oncology & carcinogenesis Molecular Medicine thymosin β4 Growth and Development Stem cell Upward migration Signal Transduction |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 |
| Popis: | The hair follicle (HF) is an important mini‐organ of the skin, composed of many types of cells. Dermal papilla cells are important signalling components that guide the proliferation, upward migration and differentiation of HF stem cell progenitor cells to form other types of HF cells. Thymosin β4 (Tβ4), a major actin‐sequestering protein, is involved in various cellular responses and has recently been shown to play key roles in HF growth and development. Endogenous Tβ4 can activate the mouse HF cycle transition and affect HF growth and development by promoting the migration and differentiation of HF stem cells and their progeny. In addition, exogenous Tβ4 increases the rate of hair growth in mice and promotes cashmere production by increasing the number of secondary HFs (hair follicles) in cashmere goats. However, the molecular mechanisms through which Tβ4 promotes HF growth and development have rarely been reported. Herein, we review the functions and mechanisms of Tβ4 in HF growth and development and describe the endogenous and exogenous actions of Tβ4 in HFs to provide insights into the roles of Tβ4 in HF growth and development. |
| Databáze: | OpenAIRE |
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