Formation and Investigation of Electrospun PLA Materials with Propolis Extracts and Silver Nanoparticles for Biomedical Applications
| Autor: | Vitalis Briedis, Alvydas Pavilonis, Sigitas Stanys, Vaida Juškaitė, Modestas Žilius, Erika Adomavičiūtė, Solveiga Pupkevičiūtė |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
business.product_category
Materials science Article Subject Single product medicine.drug_class 02 engineering and technology 010402 general chemistry 01 natural sciences Silver nanoparticle chemistry.chemical_compound Antiseptic Polylactic acid lcsh:Technology (General) Microfiber medicine General Materials Science Composite material Propolis chemistry pharmacology Silver Coated materials biocompatible Anti-bacterial agents Wound healing drug effects technology industry and agriculture 021001 nanoscience & nanotechnology Antimicrobial 0104 chemical sciences HaCaT lcsh:T1-995 615.28 [udc] 0210 nano-technology business Nuclear chemistry |
| Zdroj: | Journal of Nanomaterials, Vol 2017 (2017) Journal of nanomaterials, New York : Hindawi, 2017, vol. 2017, art. no. 8612819, p. 1-11 |
| ISSN: | 1687-4129 1687-4110 |
| DOI: | 10.1155/2017/8612819 |
| Popis: | An electrospun hydrophilic non-water-soluble biocompatible polylactic acid (PLA) nonwoven material was used as a delivery system for propolis ethanolic extract (PEE) and silver nanoparticles (AgNPs) that are known for their established antiseptic and antimicrobial activity. Combination of PEE and AgNPs in a single product should provide efficient antimicrobial protection and improved wound healing. Evaluations of PEE and AgNPs on morphology of electrospun materials, release kinetics of AgNPs and phenolic compounds, antibacterial properties, and cytotoxicity of electrospun PLA materials were performed. The presence of PEE or/and AgNPs resulted in denser mats formed by thicker PLA fibers. The average diameter of PLA microfibers was 168±29 nm. The average diameter of microfibers increased to 318±40 and 370±30 nm when 10 wt% and 20 wt% ethanol were added, respectively. Addition of 10 wt% or 20 wt% PEE increased the diameter to 282±25 and 371±25 nm, respectively. Suspension of AgNPs also caused the formation of thicker microfibers with 254±25 nm diameter. Electrospun PLA microfibers with PEE maintained viability of HaCaT cells. Testing of antimicrobial activity confirmed the ability of AgNPs containing PLA electrospun materials to inhibit the growth of microorganisms. |
| Databáze: | OpenAIRE |
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